Polysaccharide iron complex

Polysaccharide iron complex 100 150 mg capsule 50 mg tablet 100 mg/5 mL elixir... 

Carbonyl iron and polysaccharide-iron complex are reported to be associated with fewer Gl effects and are less toxic than other forms of iron. 

There is a number of synthetic substitutes for natural ferritin and the properties of these have been compared with those of ferritin. The synthetic polysaccharide iron complex (PIC), has a magnetic blocking temperature of 48K (Mohie-Eldin et al. 1994). Iron-dextran complexes are used as a substitute for ferritin in the treatment of anaemia. The iron cores of these complexes consist not of ferrihydrite, but of very poorly crystalline akaganeite with magnetic blocking temperatures of between 150 and 290 K (Muller, 1967 Knight et al. 1999) which were lowered from 55K to 35 and 25K, if prepared in the presence of 0.250 and 0.284 Al/(A1 -i- Fe), respectively (Cheng et al.2001). 

One of these approaches is the formation of polysaccharide iron complexes (PIC), such as Niferex, a compound used in the treatment of iron deficiency anemia. PICs are formed by neutralization of FeCb-containing carbohydrate solutions with base. Mineral particles of roughly the same size as ferritin cores can be made. These contain iron in an octahedral enviromnent coordinated to oxygen. However, the long-range order of the polynuclear iron core is closer to that of akaganeite rather than ferrihydrite. ... 

Sulphate Oral Solution, Paediatric 5 ml contains 12 mg of elemental iron but they stain the teeth. Polysaccharide-iron complex (Niferex) 5 ml contains 100 mg of elemental iron. There are numerous other iron preparations which can give satisfactory results. 

Ferrous sulfate (feosol, others) is the hydrated salt, FeSO 7Hff), which contains 20% iron. Ferrous fumarate (feostat, others) contains 33% iron and is moderately soluble in water, stable, and almost tasteless. Ferrous gluconate (fergon, others), which contains 12% iron, also is used in the therapy of iron-deficiency anemia. Polysaccharide—iron complex (niferex, others), a compound of ferrihydrite and carbohydrate, has comparable absorption. The effective dose of these preparations is based on iron content. 

The complex-formation of polysaccharides with alkali metals and alkaline-earth metals has already been discussed in this Series. A dextran-iron complex has been used in the experimental therapy of synovitis, and chondroitin sulfate-iron colloids have been prepared. The swelling of cellulose in aqueous solutions of zinc chloride depends on the formation of a complex with the vicinal 2- and 3- hydroxyl groups of the repeating unit. ... 

Absorption of iron by the individual varies with age, iron status, the amount and chemical form of the iron ingested, and with conditions in the gastrointestinal tract, only about 5—15% of iron in the diet being normally absorbed. Ferrous iron, as the sulphate, gluconate, fumarate or lactate or as ferrous ammonium sulphate, is appreciably taken up into the bloodstream from the duodenum, especially in the presence of ascorbic acid, a reducing agent. Little difference was found in the extent of their absorption between ferrous sulphate and the various chelates, but ferric ammonium citrate or polysaccharide complexes were only very poorly absorbed22)... 

Martin, J. P., Ervin, J. O., and Shepherd, R. A. (1966). Decomposition of the iron, aluminium, zinc and copper salts or complexes of some microbial and plant polysaccharides in soil. Soil Sci. Soc. Am. Proc. 30,196-200. 

Magnesium compounds retard cellulose depolymerization by deactivating the transition metal catalysts. In alkaline media where hydroxy-acids or products of polysaccharide degradation are present, magnesium forms stable complexes with transition metals. The formation of iron-magnesium complexes in particular is supported by interactions approximating the coordination number of iron (6) and one half the coordination number (3). 

Aeration, water-holding capacity, and permeability are all improved by humus. The frequent addition of easily decomposable organic residues leads to the synthesis of complex organics (e.g., polysaccharides) that bind soil particles into aggregates. The intimate association of clay-sized particles (layer silicates) with humus via cation (e.g., calcium, magnesium, aluminum, iron) bridges also promotes aggie-... 

Justification. Investigation of a number of gelatinous hydrous metal oxides (frequently called hydroxides, although their full structures are uncertain) has established ( ) that hydrous titanium (IV), zirconium (IV), iron (III), vanadium (III) and tin (II) oxides at least are capable of forming with enzymes insoluble complexes which are enzymically active. From the practical viewpoint hydrous titanium (IV) and zirconium (IV) oxides proved the most satisfactory. Comparatively high retentions of enzyme specific activity may be achieved (3, 4, 5). Such hydrous metal oxide materials have also proved to be suitable for the immobilisation of amino acids and peptides ( ), antibiotics with retention of antimicrobial activity ( ), polysaccharides J ), etc. 

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