Dextran iron complexes

The average adult body contains approximately 4 g of iron, of which roughly two-thirds exists in the form of hemoglobin. Treatment of certain types of anemias usually consists of dietary supplementation or the administration of therapeutic iron preparations by oral and parenteral routes. Iron is often administered by i.m. as iron-dextran complex which is ferric hydroxide and dextran containing 50 mg of iron per milliliter. 

Equations for calculating doses of elemental iron or as iron-dextran complex are as follows ... 

Haddow, A, Horning ES On the carcinogenicity of an iron-dextran complex. J Natl... 

Pharmacology Iron dextran, a hematinic agent, is a complex of ferric hydroxide and dextran for IM or IV use. The iron dextran complex is dissociated by the reticuloendothelial system, and the ferric iron is transported by transferrin and... 

Chronic renal dialysis Although serum ferritin is usually a good guide to body iron stores, the correlation of body iron stores and serum ferritin may not be valid in patients on chronic renal dialysis who are also receiving iron dextran complex. 

There is a number of synthetic substitutes for natural ferritin and the properties of these have been compared with those of ferritin. The synthetic polysaccharide iron complex (PIC), has a magnetic blocking temperature of 48K (Mohie-Eldin et al. 1994). Iron-dextran complexes are used as a substitute for ferritin in the treatment of anaemia. The iron cores of these complexes consist not of ferrihydrite, but of very poorly crystalline akaganeite with magnetic blocking temperatures of between 150 and 290 K (Muller, 1967 Knight et al. 1999) which were lowered from 55K to 35 and 25K, if prepared in the presence of 0.250 and 0.284 Al/(A1 -i- Fe), respectively (Cheng et al.2001). 

Huang, S. De Grave, E. (1999) Comparison of the core size distribution in iron dextran complexes using Mossbauer spectroscopy and X-ray diffraction. J. Inorg. Biochem. 73 227-233... 

Dextrans of low molecular weight have also been fractionated by gel chromatography. Bremner and coworkers,67 in preparing (by alkaline degradation) dextrans of low molecular weight suitable for incorporation in the clinically important iron-dextran complex, fractionated their product on Sephadex G-50, with (O M sodium chloride as the eluant. Separate fractions, ranging in Mn (as determined by osmometry) from 1510 to 4860, were obtained in this way. 

Iron-dextran complex Iron-dextrin complex... 

The distribution of Tc-diphosphonate in bone was reportedly altered by circulating iron dextran complex in an elderly woman patient undergoing scintigraphy (59). 

Iron-dextran complexes are soluble, nonionic and suitable for injection for the treatment of anaemia the complex is stable on storage in the pH range 4-11. More recently aminoethyldextran-methotrexate complexes have been prepared, the object being to influence uptake of the dmg selectively into tumour cells. Attachment of the dmg to the macromolecule allows selective uptake into malignant cells, as such cells are more active than normal cells in pinocytosis, the mechanism by which macromolecules are taken into many cells. 

Iron Dextran Complex Insulin Interferon-a2b Interleukin-2 Interleukin-6 Iodoacetate Irinotecan Iron chelate Isosafrole Itraconazole Ivermectin Ixabepilone Jateorhizine Jatrorrhizine Josamycin K02 (morpholine-urea-Phe-Hphe-vinylsulfone) KP018 K-2-11 (amphiphilic dihydropyridine antioxidant derivative) Kaempferol Kampo medicines Kansui Kava kava (Piper methysticum) ... 

Byun HH, Rodman SG, Chung KE (1976) Soft tissue concentration of Tc-99m phosphates associated with injection of iron dextran complex. J Nucl Med 17 374-375 Callahan RJ, Froelich JW, McKusick KA, Leppo J, Strauss WH (1982) A modified method for the in vivo labeling of red blood cells with Tc-99m concise communication. J Nucl Med 23 315-318... 

Dextran Iron Complex. Iron-dextran complex ... 

Iron dextran injection (INFED, DEXFERRUM) is a colloidal solution of ferric oxyhydroxide com-plexed with polymerized dextran (molecular weight -ISO IcDa) that contains 50 mg/mL of elemental iron. It can be administered by either intravenous (preferred) or intramuscular injection. When given by deep intramuscular injection, it is gradually mobilized via the lymphatics and transported to reticuloendothelial cells the iron then is released from the dextran complex. Intravenous administration gives a more reliable response. Given intravenously in a dose of less than 500 mg, the iron dextran complex is cleared with a plasma tj of 6 hours. When I g or more is administered intravenously as total dose therapy, reticuloendothelial cell clearance is constant at 10-20 mg/h. This slow rate of clearance results in a brownish discoloration of the plasma for several days and an elevation of the serum iron for 1-2 weeks. 

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