Polypeptide based synthetic compounds

Several groups of branched polypeptide based synthetic compounds were also prepared by introduction of B-cell or T-cell epitope peptides onto the side end of the branches. We have demonstrated that the efficacy of antibody response specific for a Herpes Simplex virus glycoprotein D epitope is highly dependent on the chemical structure (sequence and conformation) ofbranched polypeptide carrier. Recently a fully synthetic prototype conjugate of EAK with two independent T cell epitope peptides of... 

Teachers need to be aware of two different uses of the term electrolyte . In the strict sense, an electrolyte is a liquid that cm undergo electrolysis. This can be a single substance, as in the case of a molten salt, or a solution. The most typical electrolytes are the aqueous solutions of salts (in general of ionic compounds), of acids, and of bases. By extension, we also call electrolytes the pure substances (solid, liquid, or gaseous) that, when dissolved in water, provide liquid electrolytes. Some biological substances (such as DNA or polypeptides) and synthetic polymers (such as polystyrene sulfonate) contain multiple charged functional groups and their dissolution leads to electrolyte solutions these are termed polyelectrolytes. 

Synthetic peptide-nucleic acids (PNA, Scheme 14C) consisting of poly-N-(2-aminoethyl)glycine which is derivatized with nucleotides, are an interesting hybrid class of compounds, as they are found to form Watson-Crick base pairs with a complimentary peptide-nucleic acid, RNA, and DNA. The polypeptide backbone is achiral but chirality can be induced in the molecule or its assemblies in various ways. Tagging of the peptide-nucleic acid duplex with either L- or D-lysine leads to enantiomorphic structures with opposite CD spectra, analogous to the so-called sergeants-and-soldiers effect for polyisocyanates. When paired with RNA, the peptide-nucleic acid assumes the A-structure typical of RNA (see above). ... 

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