Polymers binding interaction

S. Takka, Propranolol hydrochloride-anionic polymer binding interaction. II Farmaco, 58 1051-1056, 2003. 

Self-assembled structures can be closed if all the potential binding sites are utilized, or open if they are not. Closed assemblies have a definite geometry and stoichiometry, while open assemblies exist as mixtures of oligomers or polymers of varying stoichiometry. In addition, the self-assembled structure can be classified as cooperative if the multiple binding interactions reinforce each other to yield enhanced stability, or trivial if the binding interactions do not cooperate in the... 

The importance of hydrophobic binding interactions in facilitating catalysis in enzyme reactions is well known. The impact of this phenomenon in the action of synthetic polymer catalysts for reactions such as described above is significant. A full investigation of a variety of monomeric and polymeric catalysts with nucleophilic sites is currently underway. They are being used to study the effect of polymer structure and morphology on catalytic activity in transacylation and other reactions. 

This report indicates that studies of polymer networks using paramagnetic probes is capable of providing information on the polymer-water interactions as well as on cation binding to the polymer network. 

Similar to micellar assemblies in water, reverse micelles have also been utilized to bring about nonspecific binding interactions in organic solvents. Akiyoshi et al. (2002) have synthesized an amphiphilic block copolymer containing PEO and an amylase chain as receptor for methyl orange (MO Chart 2.2). Amylases are insoluble and methoxy-PEO (MPEO) is soluble in chloroform. Hence, an MPEO-amylase block copolymer forms reverse micelles in chloroform. Akiyoshi et al. established the capability of the buried receptors to extract the complementary analyte by studying the ultraviolet visible (UV-vis) spectra. A solution of polymer was shaken... 

Similarly to the immunoassay definition, in an MIA or MIP-ILA the interaction of the target analyte with the imprinted polymer binding sites will provide a measurable result that allows quantification of the former. 

The coordinated mechanism proposed here for debrancher action on phosphorylase limit dextrin, although hypothetical, is consistent with the evidence that the debrancher has two distinct catalytic sites and a polymer binding site or sites that overlap or interact strongly. It accounts for the observed inhibition patterns with limit dextrin and glucose incorporation and simul-... 

Nizri G, Lagerge S, Kamyshny A, Major DT, Magdassi S. (2008) Polymer-surfactant interactions Binding mechanism of sodium dodecyl sulfate to poly(diallyldimethylammonium chloride). / Colloid Interface Sci 320 74-81. 

These inerts are mostly polymeric or oligomeric in nature and can be both nonionic and anionic. They have multiple binding / interaction sites to the interface, so that a displacement becomes improbable. Several materials have been made available to the industry [6d,ej. The chemistries range from sulfonic condensates (Morwet) or lignin sul-phonates (Reaxx) to EO-PO-block copolymers (Pluronics), comb graft polymers, acrylate based copolymers or various other block copolymers. 

---