Polymeric chiral selectors, enantiomer

There have also been examples of ligand-exchange CSPs. Schmid et al. [159] used a ligand-exchange monomer as a chiral selector. The chiral selector, monomer, cross-linker, and charged monomer were polymerized to produce monolithic capillaries capable of chiral recognition and generation of EOF. The separation is achieved due to the differences in the stability between the ternary mixed copper complexes formed by the enantiomers and the CSP. 

New types of synthetic polymeric CSP are those based on tartaramide as the selector (Andersson et al., 1996) and those based on R,R) or (S,S) trans-1,2-diaminocyclohexane (Zhong, 2005). The first one shows its best performance for strongly hydrophobic molecules, when a high alkane content in the mobile phase can be used. The second one has moderate selectivities and resolutions and a comparable loading to the cellulose-based CSP (Barnhart, 2008). It offers the possibility to reverse the elution order by choosing the other enantiomer of the chiral selector. 

Physicochemical characterisation was characterised of self-assembled nanoparticles based on glycol chitosan-bearing 5p-cholanic acid and their surfactant activity . Fluorescence spectroscopy and pulsed field gradient NMR (PFG-NMR) revealed information concerning the polydispersity of micelle polymers - chiral polymeric surfactants developed over the past decade for use as chiral selectors in the analytical separation of enantiomers . The authors suggest that polydispersity is a crucial factor in understanding the chiral interactions of these species. 

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