Polymer combinatorial libraries reagents

The purification problem in the solution-phase synthesis of combinatorial libraries is addressed in various ways. For example, for a multistep synthesis polymer-bound reagents could be used [72-75]. A complementary approach uses scavenger, such as a solid-phase-supported electrophile or nucleophile, to remove unreacted starting material after the synthesis has taken place [76-79],... 

Ley SV, Baxendale IR, Myers RM. The use of polymer-sup-ported reagents and scavengers in the synthesis of natural products. In Boldi AM, editor. Combinatorial synthesis of natural product-based libraries. Boca Raton (EL) CRC Press 2006 p 131-164. 

As a final example it should be mentioned that precondensed enones, prepared by standard Knoevenagel condensation of the aldehyde with the CH-acidic carbonyl component, when reacted with thioureas provided 1,3-thiazines 37, which are isomeric to thio-Biginelli compounds of the general formula 14 (see Figure 4.5). A published report describes the combinatorial synthesis of a library of 29 derivatives of thiazines 37 utilizing polymer-supported reagents and catalysts [168]. 

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