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POLYMER-ASSISTED SOLUTION-PHASE METHODS FOR CHEMICAL LIBRARY SYNTHESIS

POLYMER-ASSISTED SOLUTION-PHASE METHODS FOR CHEMICAL LIBRARY SYNTHESIS [Pg.149]

RAJESH V. DEVRAJ and JOHN J. PARLOW Searle/Monsanto Life Sciences Company [Pg.149]

The requirement for life sciences disciplines to discover and optimize small molecules with a heightened sense of capacity and timeliness has led to an explosion in methodologies to synthesize organic compounds in greater [Pg.149]

During the early part of this decade, most efforts in high-throughput synthesis utilized solid phase organic synthesis (SPOS) techniques.1-3 SPOS was a natural outgrowth of earlier methods used to synthesize peptides and oligonucleotides.4 This method has several advantages over traditional solution-phase synthesis  [Pg.150]

However, there are also some serious practical and theoretical constraints, including the following  [Pg.150]




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