Copolymer libraries

Lohmeijer BGG, Wouters D, Yin Z, Schubert US (2004) Block copolymer libraries using supramolecular strategies. Polym Mater Sci Eng 90 723-724... 

Becer CR, Schubert US (2009) Parallel optimization and high-throughput preparation of well-defined copolymer libraries using controlled/ living polymerization methods. Adv Polym Sci DOl 10.1007/12 2009 16... 

Parallel Optimization and High-Throughput Preparation of Well-Defined Copolymer Libraries Using Controlled/ Living Polymerization Methods... 

Abstract This chapter highlights the application of controlled/ living polymerization (CLP) techniques in automated parallel synthesizers for both optimizing reaction parameters as well as preparing copolymer libraries. Special attention is given to the use of CLP techniques for constructing well-defined copolymer libraries. Furthermore, alternative strategies for the preparation of block copolymer libraries are discussed. 

In this chapter, we will focus on the use of CLP techniques for the synthesis of systematic copolymer libraries using high-throughput approaches. Prior to that, automated parallel optimization reactions that have been performed for different CLP techniques will be discussed. At the end of this chapter there will be a highlight on the latest synthetic approaches to synthesize well-defined polymer libraries. 

The LOST properties of P(MAA)-r-(OEGMA47s) and P(MAA)-r-(OEGMAnoo) libraries were determined in buffer solutions with different pH values. As illustrated in Fig. 14, the copolymer library of P(MAA)-r-(OEGMA47s) revealed cloud points from 25 to 90 °C at pH values of 2 and 4, respectively. It was mentioned... 

Similarly, the thermal transition behavior of the members of the P(DMA)- fflf-(HPA) copolymer library was investigated using DSC. For all members of this library, single Tg were obtained, which is an indication of a good mixing of the two... 

The morphology of this supramolecular diblock copolymer library has been investigated by means of atomic force microscopy (AFM) measurements. As illustrated in Fig. 21, at first glance different morphologies were obtained for different compositions. However, interpreting the phase behavior of supramolecular block copolymers is not straightforward. There are several important parameters that play a role in the phase behavior. For instance, the amorphous phase of PEG, the crystalline phase of PEG, the metal complex, and the amorphous PSt contribute to... 

Fournier D, Hoogenboom R, Thijs HML, Paulus RM, Schubert US (2007) Tunable pH-and temperature-sensitive copolymer libraries by RAFT of methacrylates. Macromolecules 40 915-920... 

Fig. 10 Illustrations of the microchannel confined surface-initiated polymerization (p-SIP) route for producing gradient polymer brush libraries a route for making polymer molecular weight and block copolymer libraries b route for making statistical copolymer libraries. Red arrows show the flow of monomer solution from a syringe pump used to gradually fill the microchannel. See text for details...

Figure 11.17 Synthesis of the solution-phase, discrete copolymer library of soluble supports L13 and structures of monomers used for its synthesis.

FOU Fourttier, D., Hoogenboom, R., Thijs, H.M.L., Paulus, R.M., and Schubert, U.S., Tunable pH- and temperature-sensitive copolymer libraries by reversible addition-fragmentation chain transfer copolymerizations of methacrylates. Macromolecules, 40, 915, 2007. 

Figure 23 (a) Glass transition temperatures and (c) LOST of the Amor-HPA copolymer libraiy and (b) glass transition and (d) LOST of the DMA-HPA copolymer library. Adapted from Eggenhuisen, T. M. Becer, C. R. Rjten, M. W. M. etal. MacromoleculesMOi, 41 (14), 5132-5140, and reprinted with permission from the American Chemical Society. 

Qian and co-workers [129] used in-source direct pyrolysis mass spectrometry to identify 150 different polymers and copolymers. Library searching facilities were included to enable positive polymer identifications to be carried out. 

Lohmeijer, B.G.G., Wouters, D., Yin, Z. and Schubert, U.S. (2004) Block copolymer libraries modular versatility of the macromolecular lego systems. Chem. Commun., 24,2886-2887. 

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