Polyhydroxyethyl methacrylate

Hydration of polymeric membranes may be influenced by the chemical identity of the polymers. A hydrophilic polymer has a higher potential to hydrate than a hydrophobic one. Sefton and Nishimura [56] studied the diffusive permeability of insulin in polyhydroxyethyl methacrylate (37.1% water), polyhydroxy-ethyl acrylate (51.8% water), polymethacrylic acid (67.5% water), and cupro-phane PT-150 membranes. They found that insulin diffusivity through polyacrylate membrane was directly related to the weight fraction of water in the membrane system under investigation (Fig. 17). 

Polyhydroxyethyl methacrylate (phema) is more soluble in water than polymethyl methacrylate (PMMA). Cross-linked phema, which swells but does not dissolve in water, is used in soft contact lenses. 

In order to solve this problem we have introduced a chemically anchored polyhydroxyethyl methacrylate (polyHEMA) layer between the gate oxide and the polymer membrane that will contain the ion specific receptor molecules. Schema-deadly this is depicted in Figure 6. 

Highly cross-linked hydrogels of polyhydroxyethyl methacrylate,... 

Polychloroethers, Acetal polymers, Halogenated poly vinylidene fluoride Loosely cross-linked hydrogels of polyhydroxyethyl methacrylate, Polyethylene oxide, Polyvinyl alcohol or Polyvinyl pyrrolidone ... 

Polysaccharides (cellulose, agarose, dextran, chitin, chitosan), inorganic glass, polyvinylalcohol, polyhydroxyethyl methacrylate... 

A)H Dextran and alginic acid Hydroxyethyl cellulose and hydroxypropyl cellulose Polyvinyl alcohol, polyhydroxyethyl methacrylate, and low-molecular-weight polyethylene oxide... 

The structures of a number of synthetic hydrophilic polymers as a representative range of those commonly used are shown in Fig. 1. Many common hydrophilic polymers are based on methacrylate or acrylate backbones. One of the most common is polyacrylic acid, which forms the basis of many hydrogel materials (Fig. lA). Although simple polyacrylic acid is water soluble, it can be easily cross-linked to form an insoluble network polymer that still, however, retains high affinity for water and is capable of adsorbing large amounts of water to form hydrogels these are discussed later. Polymethacrylic acid-based polymers are similar in nature (Fig. IB). One of the most commonly used polymers for contact lenses, polyhydroxyethyl methacrylate, is based on a similar backbone (Fig. 1C). 

Fig. 1 Structures of some common synthetic hydrophilic polymers (A) poly aery lie acid, (B) polymethacrylic acid, (C) polyhydroxyethyl methacrylate, (D) polyvinyl alcohol, (E) polyvinyl acetate, (F) PEG/PEO, (G) polyacrylamide, (H) polyvinylpyrrolidinone, (I) Nylon 6, and (J) a simple polyurethane.

The original pin support was poly(acrylic acid) grafted onto inert polyethylene, where the carboxylic acid moieties were capped with mono Boc-protected ethyl-enediamine [79]. PS and the extremely hydrophilic polyhydroxyethyl methacrylate and poly(methacrylic add/dimethylacrylamide) were also grafted on [81]. The last grafted support in the Multipin concept is the so-called Lanterns [80], where the actual solid support is PS, which can be functionalized in a similar way to PS gel-type supports. 

Polymers containing hydroxyl groups including polysaccharide, polyvinyl alcohol and its copolymers, polyhydroxyethyl methacrylate, silica, and porous glass can be used as material supports not... 

Hydroxyl Polysaccharides (cellulose, agarose, dextran, chitin, chitosan), inorganic glass, polyvinyl alcohol, polyhydroxyethyl methacrylate Cyanogen bromide, triazine method, cyclic frans-2,3-carbonate reaction, carbonylation, periodate oxidation, epoxide activation [168-181]... 

Ethylene vinyl acetate copolymer Hexamethylene oxalate copolymer Polyhydroxyethyl methacrylate... 

No. 13, July 2001, p. 1763-9 POLYHYDROXYETHYL METHACRYLATE FILM AS A DRUG DELIVERY SYSTEM FOR PILOCARPINE... 

Details are given of pilocarpine trapped in a matrix diffusion-controlled drug delivery system using hydrophilic inserts of polyhydroxyethyl methacrylate. The physical and chemical properties of pilocarpine were investigated to determine the mechanism of drug-polymer interaction and the effect of drug release behaviour of controlled release polymeric devices. 22 refs. 

Polyhydroxyethyl methacrylate imprinted for hydrocortisone was used to absorb testosterone. Potential applications for developing drug release systems capable of modulating release with respect to the presence of specific molecules are discussed. 12 refs. 

Details are given of the preparation of collagen polyhydroxyethyl methacrylate hydrogels as implants for the delivery of anticancer drugs. The controlled release of contraceptive steroids was examined using hybrid copolymers of collagen with PEG and polyvinylpyrrolidone. 4 refs. 

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