Polyhydroxyalkanoate production technologies

Koller, M., Bona, R., Chiellini, E., Fernandes, E. G., Horvat, R, Kutschera, C., Hesse, R, and Braunegg, G. (2008). Polyhydroxyalkanoate production from whey by Pseudomonas hy-drogenovora. Bioresource Technology 99,4854-4863. 

Metabolix Inc., is a private firm based in Cambridge, Massachusetts, USA, that was spun out of the Massachusetts Institute of Technology in 1992 and acquired biopolymer technology from Monsanto Inc. in 2001. Metabolix began its first commercial production of organic polyhydroxyalkanoate (PHA) resin, based on corn sugar in 2005 at an undisclosed location in the Midwest. The plant was expected to produce around 100 tonnes of material in 2005 and close to 1000 tonnes in 2006. 

Rehm BHA (2007) Biogenesis of microbial polyhydroxyalkanoate granules a platform technology for the production of tailor-made bioparticles. Curr Issues Mol Biol 9 41-62 Reijnders L, Huijbregts MAJ (2008) Palm oil and the emission of carbon-based greenhouse... 

Many bacteria can use glycerol as a carbon source. As it is a by-product of the production of bio-diesel it can be achieved chet ly. Therefore it seems to be a good alternative to glucose for die production of Polyhydroxyalkanoates. Sodiumvalerate is often used as a precursor in order to obtain the copolymer Poly-3-hydroxybutyrate-co-3-hydroxyvalerate. As Biorelated Potymers Sustainable Polymer Science and Technology Edited by Chiellini et al., Kluwer Academic/Plenum Publishers, 2001 147... 

Ahn WS, Park SJ, Lee SY (2001) Production of poly(3-hydroxybutyrate) from whey by cell recycle fed-batch culture of recombinant Escherichia coli. Biotechnol Lett 23 235-240 Alias Z, Tan IKP (2005) Isolation of palm oil-utilising, polyhydroxyalkanoate (PHA)-producing bacteria by an enrichment technique. Bioresource Technology 96(11) 1229-1234 Alvarez HM, Kalscheuer R, Steinbuchel A (1997) Accumulation of storage lipids in species of Rhodococcus and Nocardia and effect of inhibitors and polyethylene glycol. Fett/Lipid 99 239-246... 

Neto J (2006) New strategies in the production of polyhydroxyalkanoates from glycerol and meat and bone meal. PhD thesis, Graz University of Technology... 

Poirier Y, Nawrath C, Somerville C (1995) Production of polyhydroxyalkanoates, a family of biodegradable plastics and elastomers, in bacteria and plants. Bio/technology 13 142-150... 

Akiyama, H., Okuhata, H., Onizuka, T., Kanai, S., Hirano, M., Tanaka, S., et al., 2011. Antibiotics-free stable polyhydroxyalkanoate (PHA) production from carbon dioxide by recombinant cyanobacteria. Bioresource Technology 102 (23), 11039-11042. 

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