Polycyclic aromatic hydrocarbon metabolic activation, effects

Effects of Methyl and Fluorine Substitution on the Metabolic Activation and Tumorigenicity of Polycyclic Aromatic Hydrocarbons... [Pg.91]

P.P. Fu et al., Effects of nitro substitution on the in vitro metabolic activation of polycyclic aromatic hydrocarbons, in Polycyclic Aromatic Hydrocarbon Carcinogenesis Structure-Activity Relationships, ed. by S.K. Yang, B.D. Silverman (CRC Press, Florida, 1988), pp. 37-65... [Pg.237]

Marston CP, Pereira C, Ferguson J, et al. 2001. Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on the tumor initiation, PAH-DNA binding and metabolic activation of carcinogenic PAH in mouse epidermis. Carcinogenesis 22(7) 1077-1086. [Pg.335]

Hecht, S.S., Amin, S., Melkikian, A.A., LaVoie, E.J., and Hoffmann, D. (1985) Effects of methyl and fluorine substitution on the metabolic activation and tumorigenidty of polycyclic aromatic hydrocarbons, in Polycyclic Hydrocarbons and Carcinogenesis (ed. [Pg.148]

Luch, A. and Baird, W.M. (2005) Metabolic activation and detoxification of polycyclic aromatic hydrocarbons, in The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons (ed. A. Luch), Imperial College Press, London,... [Pg.293]

Polycyclic aromatic hydrocarbons (PAH) are mainly products of incomplete combustion and can be found at high concentrations in PM. PAHs require metabolic activation to electrophiles, catalyzed by various enzymes through free radical mechanisms, to exert their carcinogenic effects. Research found that there are... [Pg.412]