Carcinogenesis, structure-activity

Yang, S.K. and Silverman, B.D., Polycyclic Aromatic Hydrocarbon Carcinogenesis Structure-Activity Relationships, CRC Press, Inc., Boca Raton, FL, 1988. 

We recently reported a structure-activity model for variations In target organs (12) and are currently examining the possible application of the quantitative structure-activity approach to the problem of specles-to-specles differences In susceptibility toward nltrosamlne carcinogenesis (19). These two topics will be discussed In the remainder of this presentation. 

Recent structure-activity studies of 1-alkylbenzo[a]pyrenes also suggest that DNA intercalation of benzo[a]pyrene (BP) metabolites plays a role in the mechanism of BP carcinogenesis (38). The addition of bulky alkyl groups at the 1-position of BP, which inhibit DNA intercalation of 1-alkyl-BP metabolites (19), causes a reduction in carcinogenic activity. 

Moser GJ, Robinette CL, Smart RC. 1993. Characterization of skin tumor promotion by mirex structure-activity relationships, sexual dimorphism and presence of Ha-ras mutation. Carcinogenesis 14(6) 1155-1160. 

Mechanisms of Chemical Carcinogenesis and Structure-Activity Relationship (SAR)... 

Kurata, Y, Fukushima, S., Hasegawa, R., Hirose. M.. Shibata, M.-A., Shirai, T. Ito, N. (1990) Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants. Jpn. J. Cancer Res., 81, 754-759... 

Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic... 

Enslein, K., and P. N. Craig. Carcinogenesis A predictive structure-activity model. J. Toxicol. Environ. Health 10 521, 1982. 

Franke, R., Gruska, A., Giuliani, A., and Benigni, R., Prediction of rodent carcinogenicity of aromatic amines a quantitative structure-activity relationships model, Carcinogenesis, 22, 1561-1571, 2001. 

R. Benigni, C. Andreoli, and A. Giuliani, Carcinogenesis, 10, 55 (1989). Structure-Activity Studies of Chemical Carcinogens Use of an Electrophilic Reactivity Parameter in a New QSAR Model. 

Gelderblom WCA, Cawood ME, Snyman SD, Marasas WFO Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assays. Food Chem Toxicol 1993 31 407-414. 

The 28 descriptors selected in this study are a notably diverse set. All types of descriptors available have been found useful in the analysis. One can interpret this selection of such a diverse set of descriptors as an indication that PAH carcinogenesis is a complex process involving many factors, and that one might expect the most success at developing structure-activity relationships with a multifaceted approach to the problem. 

Niculescu-Duvaz I, Craescu T, Tugulea M, Croisy A, Jacquignon PC. A quantitative structure-activity analysis of the mutagenic and carcinogenic action of 43 structurally related heterocyclic compounds. Carcinogenesis 1981 2 269-75. 

Benigni R, Andreoli C, Giuliani A. Structure-activity studies of chemical carcinogens Use of an electrophilic reactivity parameter in a new QSAR model. Carcinogenesis 1989 10 55-61. 

Structure-activity relationship analysis has proven to be useful in evaluating carcinogenicity of a chemical and is considered as a part of weight of evidence by providing valuable information on chemicals or metabolites that initiate carcinogenesis. Increasing... 

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