Polyamines functions

Anion exchange resins- —gel type—weakly basic—polyamine functionality ... 

Hydrophilicity and hydrophobicity are the most fundamental properties to be controlled for materials whenever they are utilized in biomedical devices. Protein-adsorption behavior on several biomaterials of different hydrophilicity was discussed by comparing available data with two modellings (Ikada and Peppas) for the protein-adsorption process. The adsorptive behavior of poly(HEMA) carrying polyamine functional groups was also discussed. It is well-known that protein adsorption is the first event when any of the body fluids encounters an artificial material. 

Carboxylic acids generated in acylation reactions have been effectively sequestered by ion pair formation with Amberlite IRA-68 ion exchange resin.29 3 Similarly, 4-nitrophenoxide formed in acylations of 4-nitrophenyl esters has been captured by anion exchange with the quaternary ammonium hydroxide resin 12.31 An exception to ion pair-mediated sequestration of byproducts is the polyamine functionalized resin 3 that was shown to covalently sequester the (3-methoxy enone hydrolysis byproduct from Danishefsky s diene via imine formation.23... 

Womer C, Miilhaupt R (1993) Polynitrile-functional and polyamine-functional poly(trimethy-lene imine) dendrimers. Angew Chem Int Ed Engl 32 1306-1308... 

Neamine analogues have been prepared in several studies in order to explore their potential as small molecule antitumour and anti-HIV agents, as well as bacterial enzyme inhibitors. 5-0-Alkylated neamines with polyamine functionality in the side-chain have been synthesized from 5-0-allylated precursors and these were found to exhibit high binding affinity for oncogene fusion proteins. The acylation of neamines at N-6 with aromatic units was carried out to explore the effect of these substituents on the interaction of neamine aminoglycosides with HIV RNA. Pyrene substituents were found to impart the most effective level... 

Wbmer C, MUlhaupt R (1993) Polynitrile- and polyamine-functional poly(trimethylene... 

Polyalkylene polyamines find use in a wide variety of appHcations by virtue of their unique combination of reactivity, basicity, and surface activity. With a few significant exceptions, they ate used predominantly as intermediates in the production of functional products. End-use profiles for the various ethyleneamines ate given in Table 6. 

Many of the surfactants made from ethyleneamines contain the imidazoline stmcture or are prepared through an imidazoline intermediate. Various 2-alkyl-imidazolines and their salts prepared mainly from EDA or monoethoxylated EDA are reported to have good foaming properties (292—295). Ethyleneamine-based imida zolines are also important intermediates for surfactants used in shampoos by virtue of their mildness and good foaming characteristics. 2- Alkyl imidazolines made from DETA or monoethoxylated EDA and fatty acids or their methyl esters are the principal commercial intermediates (296—298). They are converted into shampoo surfactants commonly by reaction with one or two moles of sodium chloroacetate to yield amphoteric surfactants (299—301). The ease with which the imidazoline intermediates are hydrolyzed leads to arnidoamine-type stmctures when these derivatives are prepared under aqueous alkaline conditions. However, reaction of the imidazoline under anhydrous conditions with acryflc acid [79-10-7] to make salt-free, amphoteric products, leaves the imidazoline stmcture essentially intact. Certain polyamine derivatives also function as water-in-oil or od-in-water emulsifiers. These include the products of a reaction between DETA, TETA, or TEPA and fatty acids (302) or oxidized hydrocarbon wax (303). The amidoamine made from lauric acid [143-07-7] and DETA mono- and bis(2-ethylhexyl) phosphate is a very effective water-in-od emulsifier (304). 

In addition we studied the complexation of ClC+ by the polyamines using microcalorimetry and potentiometry. The enthalpy changes measured are presented as function of the degree of protonation and the amount of CiT bound. 

Macrocyclic polyamines may be viewed as an extended form of linear polyamines 13-161 with one less degree of saturation. Polyamines with lower degrees of saturation, have important biological functions. Compounds such as macrocyclic polyimines 171 and porphyrines 18), function as 02 carriers and activators, promote photosynthesis, form the basic structure of vitamine B12, etc., and for these reasons have been subjects of intense investigation. 

Bichrach, U. (ed.) Function of Naturally Occurring Polyamines, Academic Press, New York and London 1973... 

Even with elastomers, it is often desirable to phase mix the material for certain combinations of physical properties. For example, elastomers with high hardness and flexural modulus are prepared from polyisocyanates, polyols, and polyamines of high functionality, creating a high crosslink density. Although polyol chains... 

The polyamines spermidine and spermine (Figure 31-4) function in cell proliferation and growth, are growth factors for culmred mammalian cells, and stabilize intact cells, subcellular organelles, and membranes. Pharmacologic doses of polyamines are hypothermic... 

Lu CD, Y Itoh, Y Nakada, Y Jiang (2002) Functional analysis and regulation of the divergent spuABCDEFGH-spul operons for polyamine uptake and utilization in Pseudomonas aeruginosa PAOl. J Bacteriol 184 3765-3773. 

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