Poly 2-hydroxyethylmethacrylate

FIGURE 6.23 The release of thiamine HC1 from a glassy poly(2-hydroxyethylmethacrylate) sheet. [Graph reconstructed from data by P. I. Lee, in Controlled-Release Technology Pharmaceutical Applications, P. I. Lee and W. R. Good (Eds.), ACS Symp. Ser. No. 348, American Chemical Society, Washington, D.C., 1987. p. 71.]... 

The carboxylic groups of mesoporphyrin-lX 15 b) and mesohemin-IX 15 c) were converted into isocyanate groups 15 d, e). The reaction with hydroxji group containing crosslinked polymers like poly(2-hydroxyethylmethacrylate) or sephadex (with hydroxy-propyl groups) in pyridine at room temperature led to fixed porjAyrins 20 a, b). 

The reaction can be used to introduce chromophores onto the surface of polymeric films containing hydroxy groups. When a poly(2-hydroxyethylmethacrylate) (PHEMA) film 14 was immersed in an acetonitrile solution of dimethyl terephthalate (DMTP) and l-methyl-2-arylcy-clopropane 13 (where the aryl group is 1-pyrenyl or 9-phenanthryl) and then irradiated at 313nm, a chemically modified film 15 was obtained that gives absorption and fluorescence spectra similar to 13, and therefore may be useful as a photocatalyst, photochromic device etc. - ... 

Li, X., Cui, Y. (2008). Study on synthesis and chloramphenicol release of poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels. Chinese Journal of Chemical Engineering 16 640-645. 

In this paper we have described the separation and characterization of four polymers by ITP Ccurboxymethylcellulose (CMC) (11) with degree of substitutions of 0.4-1.2 carboxymethyl group poly(2-hydroxyethylmethacrylate-co-2-acrylamido-2-methylpropanesulfonate)... 

Rh2H2(CO)2[Ph2P(O(CH2)2)400OPKl2]3-poly(2-hydroxyethylmethacrylate) network coating on porous silica, c-C6Hj2, CO/H2(l/l,800psi), 85°, 4 h... 

Poly(2-hydroxyethyl acrylate-co-2-hydroxyethyl methacrylate) Poly(2-hydroxyethyl acrylate-co-hydroxypropyl acrylate) Poly(2-hydroxyethyl acrylate-co-vinyl butyl ether) Poly(2-hydroxyethyl methacrylate-g-ethylene glycol) Poly(2-hydroxyethylmethacrylate-6-A -isopropylacrylamide) Poly(2-hydroxyisopropyl acrylate-co-aminoethyl methacrylate) Poly(2-hydroxypropyl acrylate-co-A -acryloylmorpholine) Poly(2-hydroxypropyl acrylate-co-aminoethyl methacrylate) Poly(2-hydroxypropyl acrylate-co-A. A -dimethylaciylamide) Poly[A -(2-hydroxypropyl)methacrylamide-Zr-A -isopropylacrylamide] Poly [A -(2-hydroxypropyl)methacrylamide monolactate-co-A -(2-hydroxypropyl) methacrylamide dilactate]... 

Thus, particles with a very narrow distribution were observed - in the case of a second generation dendrimer, nanoparticles with a monodisperse nucleus of 2.4 0.2 nm. It is important that not only individual dendrimers can be used for metallopolymer preparation, but also their dispersed mixtures with polymer matrices, which form new types of polymer-inorganic nanomaterials. For example, the highest poly(amidoamide) generations in water were put in swollen polymeric patterns of poly(2-hydroxyethylmethacrylate) Cu, Au or ions of a complex bound to dendrimer [90] were added to such a composition. Reduction of the metal ions resulted in new types of inorganic hybrid materials. 

Figure 2.19 Like Janus, poly(2-hydroxyethylmethacrylate) (PHEMA) has two faces. The face presenting the carbon-carbon chain and methyl groups is hydrophobic. The face presenting the hydroxyethyl esters is hydrophilic.

Crosslinked poly(2-hydroxyethylmethacrylate), PHEMA, has been prepared by radical polymerization in presence of different amounts of water and water-diacetine solutions. While homogeneous samples can be prepared at all water-diacetine content, amounts of water higher than 40% causes the formation of macroporous opaque sponges. Mechanical properties of water swollen samples have been measured and related to the crosslink formation during the polymerization process. From water diffusion kinetics in sorption and desorption experiments at 37 C the diffusion coefficients have been calculated. Measurements of the swelling at equilibrium in water-diacetine mix-res indicate the presence of "cosolvency" phenomenon for the samples studied. 

The results reported in this work showed that mechanical and transport properties of Poly-2-hydroxyethylmethacrylate are strongly affected by the composition of the reaction mixture, and in particular by the ratio water/diacetine. It has been shown that it is possible, using different types and amounts of additives, to obtain a wide range of physical properties of swollen PHEMA as required for various biomedical applications. Moreover, the spongy samples could be of interest in the design of biomedical implants whose morphology is characterized by porous structure with very high water contents. 

Peschier, L. J. C., Bouwstra, J. A., de Bleyser, J., Junginger, H. E., and Le5de, J. C., 1993, Water mobility and structure in poly[2-hydroxyethylmethacrylate] hydrogels by means of the pulsed field gradient NMR technique. Biomaterials 14 945-952. 

PHBA-COOR PHBA-COOH after coupling with 4-amino-TEMPO PHEMA poly(2-hydroxyethylmethacrylate)... 

Rani GU, Mishra S, Pathak G, Jha U, Sen G. Synthesis and applications of poly(2-hydroxyethylmethacrylate) grafted agar a microwave based approach. Int J Biol Macromol 2013 61 276-284. 

Santin, M., Huang, S. J., lannace, S., et al. (1996) Synthesis and characterization of a new interpenetrated poly(2-hydroxyethylmethacrylate)-gelatin composite polymer. Biomaterials, 17, 1459-67. 

Photoresponsive gels based on the photon mode work by cis-trans photoisomerism of photochromic molecules like azobenzene or by photoionization of triphenylmethanelqyco. Ishihara et al. found that poly(2-hydroxyethylmethacrylate) gel shrinks upon ultraviolet irradiation after equilibrium swelling is reached in water [33]. They fiirther found that this gel swells again upon irradiation by visible light. Azobenzene isomerizes... 

Costantini, A., Luciani, G., Silvestri, B., Tescione, F., Branda, F., 2008. Bioactive poly(2-hydroxyethylmethacrylate)/silica gel hybrid nanocomposites prepared by sol-gel process. Journal of Biomedical Materials Research B 86B, 98—104. 

Water swollen gels produced from several different polymers have been tested with this apparatus, including crosslinked cellulose ethers, poly(N-isopropylacrylamide), and poly(2-hydroxyethylmethacrylate). Typical plots of stress vs. are shown in... 

Swelling experiments have been used to determine the crosslink density of water swollen poly(vinyl alcohol) and poly(2-hydroxyethylmethacrylate) gels [28]. However, this method Is less valuable for water absorbent polymers than It is for organic systems. First of all, obtaining a meaningful value of aqueous systems is difficult due to weaknesses in the theory for systems with extensive hydrogen bonding. If Xi is used... 

New SPE films based on photo-polymerised poly (2-hydroxyethylmethacrylate) PHEMA with neopentyl glycolmethacrylate (NPGMA) as a cross-linker were prepared, the synthetic route of the photo-polymerised and crosslinked PHEMA is shown in Fig. 12.6. 

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