Poly-alpha-hydroxy acids

Poly(alpha-hydroxy acids) with seeded Schwann cells or Schwann cell grafts were also found to be effective candidates for spinal cord... 

A.S. Sawhney, C.P. Pathak, J.A. Hubbell, Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers. Macromolecules 26 (1993) 581-587, doi 10.1021/ma00056a005. 

Y. Kimura, K. Shirotani, H. Yamane, T. Kitao, Ring-opening polymerization of 3(S)-[(benzyloxycarbonyl)methyl]-l,4-dioxane-2,5-dione a new route to a poly(alpha-hydroxy acid) with pendant carboxyl groups. Macromolecules 21 (1988) 3338-3340, doi 10.1021/ma00189a037. 

Meikle MC, Mak WY, Papiaoannou S, Davies EH, Mordan N, Reynolds JJ. Bone-derived growth factor release from poly(alpha-hydroxy acid) implants in vitro. Biomaterials 1993 14 177-83. 

Piskin, E., Bolgen, N., Egri, S. and Isoglu, I. 2007. Electrospun matrices made of poly(alpha-hydroxy acids) for medical use. 2 441-457. 

Key words poly(alpha-hydroxy acids), degradation rate, polyglycolide, polylactide, degradation. 

Li, S.M., Garreau, H., Vert, M., 1990a. Structure-property relationships in the case of the degradation of massive aliphatic poly-(alpha-hydroxy acids) in aqueous media. Part 1 poly (DL-lactic acid). Journal of Materials Science Materials in Medicine 1, 123—130. 

Zhang, R.Y., Ma, P.X., 2000. Degradation behavior of porous poly(alpha-hydroxy acids)/ hydroxyapatite composite scaffolds. Abstracts of Papers of the American Chemical Society 220, U251. 

INJECTABLE MICROCAPSULES PREPARED WITH BIODEGRADABLE POLY(ALPHA-HYDROXY) ACIDS FOR PROLONGED RELEASE OF DRUGS... 

Poly(R-) and poly(S-P-malic acid)s were synthesized from the two optical isomers of malic acid and of aspartic acid. The family of malic acid based polymers includes also the alpha isomers, i.e. polymers where malic acid repeating rmits are linked through the alpha hydroxy acid part of the molecule. ... 

Moon S I, Urayama H, Kimura Y (2003), Structual characterization and degradability of poly(L-lactic acid)s incorporating phenyl-substituted alpha-hydroxy acids as... 

Lim et al. [114] synthesized a biodegradable ester analog of polylysine, poly[alpha-(4-aminobutyl)-L-glycolic acid] (PAGA). While the polymer displayed no cytotoxicity, only modest transfection activity was observed. This maybe due to a too fast hydrolysis and, similar to polylysine, the lack of efficient endosomal escape functionality. Another biodegradable cationic polyester, poly (4-hydroxy-L-proline ester) showed similar characteristics [115]. 

HAS 1,3,5-triazine-2,4,6-triamine, N,N [1,2-ethane-diyl-bis[[[4,6-bis[butyl(1,2,6,6-pentamethyl-4-piperidinyl) amino]-1,3,5-triazine-2-yl]imino]-3,1 -propanediyl]bis[N ,N -dibutyl-N ,N -bis(1,2,2,6,6-pentamethyl-4-piperidinyl)- bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate and methyl 1,2,2,6,6-pentamethyl-4-piperidyl sebacate bis(1,2,2,6,6-pentamethyl-4-piperidyl)sebacate + methyl-1,2,2,6,6-pentam-ethyl-4-piperidyl sebacate bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate poly[[(6-[1,1,3,3-tetramethylbutyl)amino]-1,3,5-triazine-2,4-diyl][2,2,6,6-tetramethyl-4-piperidinyl)imino]-1,6-hexanediyl[2,2,6,6-tetramethyl-4-piperidinyl)imino]] C20-24-. alpha.-, polymers with maleic anhydride, reaction products with 2,2,6,6-tetramethyl-4-piperidinamine 1,6-hexanediamine, N,N -bis(2,2,6,6-tetramethyl-4-piperidinyl)-, polymers with morpholine-2,4,6-trichloro-1,3,5-triazine reaction products, methylated Phenolic antioxidants ethylene-bis(oxyethylene)-bis(3-(5-tert-butyl-4-hydroxy-m-tolyl)-propionate) pentaeryth-ritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate) 3,3 ,3 ,5,5 ,5 -hexa-tert-butyl-a,a ,a -(mesitylene-2,4,6-triyl) tri-p-cresol 1,3,5-tris(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3,5-triazine-2,4,6(1 H,3H,5H)-trione isotridecyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate 2,2 -ethylidenebis (4,6-di-tert-butylphenol) 3,5-bis(1,1-dimethyethyl)-4-hydroxy-benzenepropanoic acid. Cl 3-15 alkyl esters ... 

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