Polarity therapy

Polarity therapy is based on the concept of the energy flow between the five energy centers or chakras in the body. Polarity therapy was developed over the course of 50 years by Randolph Stone (1890-1983), an Austrian-born naturopath, chiropractor, and osteopath, who also took an interest in the theories and practice of Eastern medicine and in spirituality. Polarity therapy is a holistic system of healing, based on Stone s belief that humans are predominantly spiritual beings whose health and happiness depend on the free flow of energy within their bodies (Thomas, 1997 and General References). 

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Diet doesn t stand all by itself as the path to good health. We all need exercise, fresh air, sunshine, enough sleep, recreation, and sufficient self-discipline to stop and smell the roses now and then. Of all the varied professions in the healing arts, including aU the alternative healing arts, none of them can heal damaged tissue without nutrition. Certainly drugs can t build new tissue. Nor can polarity therapy, acupuncture, or herbs. 

The compound shown is diethylstilbestrol (DES) it has a number of therapeutic uses in estrogen replacement therapy DES is not a steroid but can adopt a shape that allows it to mimic estrogens such as estradiol (p 1100) and bind to the same receptor sites Construct molecular models of DES and estradiol that illustrate this similanty in molecular size shape and location of polar groups... 

Lamotngine (Lamictal). Lamotrigine, another anticonvulsant used to treat BPAD, is currently FDA approved for the prevention of both depressive and manic episodes during BPAD maintenance therapy. This represents a shift in the paradigms for BPAD therapy, as medications used to treat acute episodes have also typically been used for antimanic prophylaxis. Lamotrigine is not effective in the acute treatment of mania but has become for many the drug of choice for bipolar depression as well as for prevention of subsequent mood episodes of either polarity. 

The pharmacokinetics of cardiac glycosides (A) are dictated by their polarity, i.e the number of hydroxyl groups. Membrane penetrability is virtually nil in ouabain, high in digoxin, and very high in digitoxin. Ouabain (g-strophanthin) does not penetrate into cells, be they intestinal epithelium, renal tubular, or hepatic cells. At best, it is suitable for acute intravenous induction of glycoside therapy. 

Banov MD, Zarate CA, Tohen M, et al. Clozapine therapy in refractory affective disorders polarity predicts response in longterm follow-up. J Clin Psychiatry 1994 55 295-300. 

Methotrexate acts by inhibition of dihydrofolate reductase, the enzyme requisite for the reduction of dihydrofolic acid (3) to 5,6,7,8-tetrahydrofolic acid (4). In turn, (4) is a precursor to a series of enzyme cofactors (5-7) essential for the transfer of one carbon unit necessary for the biosynthesis of purines and pyrimidines and hence, ultimately, DNA. As an inhibitor of dihydrofolate reductase, methotrexate kills cells during the S phase of the cell cycle, when the cells are in the log phase of growth. Unfortunately, this cytotoxicity is non-selective, and rapidly proliferating normal cells, e.g., gastrointestinal epithelium cells and bone marrow, are dramatically affected as well. In addition, recent use of high dose methotrexate therapy with leucovorin rescue has led to additional clinical problems arising from a dose-related nephrotoxic metabolite, 7-hydroxy methotrexate (8). Finally, the very polar nature of methotrexate renders it virtually impenetrable to the blood-brain barrier, which can necessitate direct intrathecal injection in order to achieve therapeutic doses for the treatment of CNS tumours. 

Gene delivery into eukaryotic cells is commonly performed for research purposes as well as in gene therapy procedures. Cellular membranes do not spontaneously take up ectopic nucleic acid because of the polar nature of the phospholipid bilayer [1] which functions as a natural barrier that prevents entry of most water-soluble molecules such as nucleic acids. In studies of gene or protein function and regulation, manipulation of the intracellular expression level is a fundamental approach. For this reason, multiple methods for delivery of nucleic acids through membranes using chemical, physical, or biological systems have been established in the last 40 years. 

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