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Polar complexing groups

The stereocontrol of the Strecker reaction (eq. 10) can be explained by steric, stereoelectronic and complexing effects of the carbohydrate. The delocalization of the C=N-tc-electron pair into the ring-C-0-a -orbital should favour the conformation I of the aldimines 25, as is demonstrated by a strong NOE between the aldimine and the anomeric proton. The constellation of the polar complexing groups at the carbohydrate framework obviously promotes the attack of the Lewis-acid catalyst at the front-site of the molecule (formula... [Pg.196]

Cholesterol is a principal component of animal cell plasma membranes, and much smaller amounts of cholesterol are found in the membranes of intracellular organelles. The relatively rigid fused ring system of cholesterol and the weakly polar alcohol group at the C-3 position have important consequences for the properties of plasma membranes. Cholesterol is also a component of lipoprotein complexes in the blood, and it is one of the constituents oiplaques that form on arterial walls in atherosclerosis. [Pg.255]

The initial step is the coordination of the alkyl halide 2 to the Lewis acid to give a complex 4. The polar complex 4 can react as electrophilic agent. In cases where the group R can form a stable carbenium ion, e.g. a tert-buiyX cation, this may then act as the electrophile instead. The extent of polarization or even cleavage of the R-X bond depends on the structure of R as well as the Lewis acid used. The addition of carbenium ion species to the aromatic reactant, e.g. benzene 1, leads to formation of a cr-complex, e.g. the cyclohexadienyl cation 6, from which the aromatic system is reconstituted by loss of a proton ... [Pg.120]

Rhodium precipitation in solubilized rhodium-phosphite complex catalyzed liquid recycle hydroformylation may be minimized or prevented by carrying out product recovery in the presence of an organic polymer containing polar functional groups such as amides, ketones, carbamates, ureas and carbonates.[20] Patent examples include the use of polyvinylpyrrolidone and vinylpyrrolidone-vinyl acetate copolymer with diorganophosphite-modified rhodium catalysts. [Pg.23]

The well balanced electronic and coordinative unsaturation of their Ru(II) center accounts for the high performance and the excellent tolerance of these complexes toward an array of polar functional groups. This discovery has triggered extensive follow up work and carbenes 1 now belong to the most popular metathesis catalysts which set the standards in this field [3]. Many elegant applications to the synthesis of complex target molecules and structurally diverse natural products highlight their truely remarkable scope. [Pg.47]

The ruthenium carbene catalysts 1 developed by Grubbs are distinguished by an exceptional tolerance towards polar functional groups [3]. Although generalizations are difficult and further experimental data are necessary in order to obtain a fully comprehensive picture, some trends may be deduced from the literature reports. Thus, many examples indicate that ethers, silyl ethers, acetals, esters, amides, carbamates, sulfonamides, silanes and various heterocyclic entities do not disturb. Moreover, ketones and even aldehyde functions are compatible, in contrast to reactions catalyzed by the molybdenum alkylidene complex 24 which is known to react with these groups under certain conditions [26]. Even unprotected alcohols and free carboxylic acids seem to be tolerated by 1. It should also be emphasized that the sensitivity of 1 toward the substitution pattern of alkenes outlined above usually leaves pre-existing di-, tri- and tetrasubstituted double bonds in the substrates unaffected. A nice example that illustrates many of these features is the clean dimerization of FK-506 45 to compound 46 reported by Schreiber et al. (Scheme 12) [27]. [Pg.60]

Symmetrical premetallised 1 2 metal-dye complexes of unsulphonated monoazo structures with aluminium (5.57) or trivalent iron (5.58) have been patented recently for use as solvent dyes [36]. They contain a polar methoxypropylaminosulphone grouping in each diazo component and are marketed as alkylamine salts. It remains to be seen, however, whether a full colour gamut of bright aluminium and iron complex dyes can be discovered with light fastness performance equivalent to that of currently available chromium and cobalt complex dyes. [Pg.259]

Separation is based on the reversible chelate-complex formation between the chiral selector covalently bonded to the chromatographic support, and the chiral solute with transition metal cations. Chelation properties of both the chiral selector and the chiral solute are required. Compounds therefore need to have two polar functional groups in a favorable arrangement to each other, like a )3-amino acids, amino alcohols and a-hydroxy acids, which can form rings membered with central chelating metal ions, like Cu(II), Zn(II), Cyclic... [Pg.468]

Although the structure of the complex arising from I52/CH2CI2 is not clear, this catalyst is excellent in terms of ease of preparation. The catalyst is very active for formation of cycloalkynes with ring sizes different from those of diynes (Table 6.5). In contrast to tungsten alkylidyne complex 150, catalyst 152/ CH2CI2 is sensitive toward an acidic proton such as amide proton and exhibited remarkable tolerance towards many polar functional groups (Table 6.5). [Pg.200]


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Polarization complex

Polarizing groups

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