Poisoning reference system

The earliest practical use of an expert system was made in the software named MYCIN for diagnosing a toxic poison from the symptoms of a patient and recommending the antidote (62). This type of activity is generally carried out by a human expert who processes information about a situation (in this case, symptoms of a patient), refers to the expert s experience and expert knowledge, and then recommends action (in this case, the antidote). 

In selecting reference electrodes for practical use, one should apply two criteria that of reducing the diffusion potentials and that of a lack of interference of RE components with the system being studied. Thus, mercury-containing REs (calomel or mercury-mercuric oxide) are inappropriate for measurements in conjunction with platinum electrodes, since the mercury ions readily poison platinum surfaces. Calomel REs are also inappropriate for systems sensitive to chloride ions. 

Many pesticides are neurotoxicants poisoning the nervous system. A number of pesticides are acetyl cholinesterase inhibitors (Serat and Mengle 1973). Generally, pesticides determination has been performed by GC since the 1960 s (Morrison and Durham 1971 Fournier et al. 1978). There are no reference materials for pesticides in urine or serum, although as with PAHs there are a number biological matrices certified for the content of various pesticides available for environmental food and agriculture analysis and which may have some application in clinical chemistry. 

Catalyst deactivation refers to the loss of catalytic activity and/or product selectivity over time and is a result of a number of unwanted chemical and physical changes to the catalyst leading to a decrease in number of active sites on the catalyst surface. It is usually an inevitable and slow phenomenon, and occurs in almost all the heterogeneous catalytic systems.111 Three major categories of deactivation mechanisms are known and they are catalyst sintering, poisoning, and coke formation or catalyst fouling. They can occur either individually or in combination, but the net effect is always the removal of active sites from the catalyst surface. 

The term microbial toxin is usually reserved by microbiologists for toxic substances produced by microorganisms that are of high molecular weight and have antigenic properties toxic compounds produced by bacteria that do not fit these criteria are referred to simply as poisons. Many of the former are proteins or mucoproteins and may have a variety of enzymatic properties. They include some of the most toxic substances known, such as tetanus toxin, botulinus toxin, and diphtheria toxin. Bacterial toxins may be extremely toxic to mammals and may affect a variety of organ systems, including the nervous system and the cardiovascular system. A detailed account of their chemical nature and mode of action is beyond the scope of this volume. 

Charcoal does not bind iron, lithium, or potassium, and it binds alcohols and cyanide only poorly. It does not appear to be useful in poisoning due to corrosive mineral acids and alkali. Recent studies suggest that oral activated charcoal given alone may be just as effective as gut emptying followed by charcoal. Also, other studies have shown that repeated doses of oral activated charcoal may enhance systemic elimination of some drugs (including carbamazepine, dapsone, and theophylline) by a mechanism referred to as "gut dialysis."... 

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