Biosynthesis lignan

Davin L, Lewis NG (2003) An historical perspective on lignan biosynthesis monolignol,... 

Hemmati S, Schmidt TJ, Fuss E (2007) (-l-)-Pinoresinol/(-)-lariciresinol reductase from Liman perenne himmelszelt involved in the biosynthesis of justicidin B. FEBS Lett 581 603-610 Umezawa T, Davin LB, Yamamoto E et al (1990) Lignan biosynthesis in Forsythia species. J Chem Soc Chem Commun 1405-1408... 

Nakatsubo T, Mizutani M, Suzuki S et al (2008) Characterization of Arabidopsis thaliana pinoresinol reductase, a new type of enzyme involved in lignan biosynthesis. J Biol Chem 283 15550-15557... 

Tazaki H, HayashidaT, IshikawaFet al (1999) lignan biosynthesis of liverworts Jamesoniella autumnalis and Lophocolea heterophylla. Tetrahedron Lett 40 101-104... 

Using the crystal structures of two related RED enzymes of lignan biosynthesis, a provisional molecular model has been produced for the M. sativa IFR. A smaller binding pocket in the protein, in comparison to the other enzymes, is suggested to account for the specific enantiomer binding and processing of IFR. 

The reductive sequence from an appropriate cinnamic acid to the corresponding cinnamyl alcohol is not restricted to lignin and lignan biosynthesis, and is utilized for the production of various phenylpropene derivatives. Thus cinnamaldehyde (Figure 4.23) is the principal component in the... 

Lewis NG and Davin LB (1999) Lignans biosynthesis and function. Comprehensive Natural Products Chemistry, Vol 1. Elsevier, Amsterdam, pp 639-712. 

Fig. 2 Lignan biosynthesis (taken from [1] by permission from Kluwer)...

There are also many examples that highlight the stereochemical diversity of lignan biosynthesis, as observed in a cell-free extract of Arctium lappa petiole [35], which afforded secoisolariciresinol with the opposite antipode (+) to that formed by Forsythia spp. 

Umezawa T, Davin LB, Yamamoto E, Kingston DAI, Lewis NG (1990b) Lignan biosynthesis in Forsythia species J Chem Soc Chem Commun 1405-1408... 

Davin, F.B. and Fewis, N.G. (2003) An historical perspective on lignan biosynthesis monolignol, allylphenol and hydroxycinnamic acid coupling and downstream metabolism. Phytochemistry Rev., 2, 257-88. 

Kuhlmann, S., Kranz, K., Lucking, B., Alfermann, A.W. and Petersen, M. (2002) Aspects of cytotoxic lignan biosynthesis in suspension cultures of Linum nodiflorum. Phytochemistry Rev., 1, 37-43. 

Kwon, M., Buriat, V., Davrn, L.B. and Lewis, N.G. (1999) Localization of dirigent protein involved in lignan biosynthesis implications for lignification at the tissue and subcellular level. Basic Life Sci., 66, 393-411. 

Suzuki, S. (2002) Stereochemical diversity in lignan biosynthesis and establishment of norlignan biosynthetic pathway. Wood Res., 89, 52-60. 

Suzuki, S., Umezawa, T., Shimada, M. (2002b) Stereochemical diversity in lignan biosynthesis of Arctium lappa L. Biosci. Biotechnol. Biochem., 66,1262-9. 

Umezawa, T., Okunishi, T. and Shimada, M. (1998) Stereochemical differences in lignan biosynthesis between Arctium lappa, Wikstroemia sikokiana, and Forsythia spp. ACS Symp. Ser., 697, 377-88. 

Brunow G, Kilpelainen I, Sipila 1, Syijanen K, Karhunen P, Setala H, Rummakko P (1998) In Lewis NG, Sarkanen S (eds) Lignin and lignan biosynthesis. ACS Symp Ser 697 131... 

Atalla RH (1996) Cellulose and the hemicelluloses patterns for the assembly of lignin. In Lewis NG and Sarkanen S (eds), Lignin and lignan biosynthesis. American Chemical Society, Washington, DC, 172-9... 

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