Pneumonia pathogenesis

Pneumocystis carinii Pneumonia Pathogenesis, Diagnosis, and Treatment, edited by L. S. Young... 

Schelf WM, Mandell GL. Nosocomial pneumonia pathogenesis and recent advances in diagnosis and therapy. Rev Infect Dis 1991 13 S743-S751. 

Takashima, K. et al., Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice, Infect. Immun., 65, 257, 1997. 

Despite the protective effect of NO against various viral infections, workers in several studies have shown a harmful role of NO in many systems. NO seems to play a part in the development of pneumonia caused by influenza virus [128], in the pathogenesis in mice of tick-borne encephalitis flavivirus infection [131], and in worsening the course of the murine myocarditis caused by coxsackievirus B3 [132]. In addition, pneumonia in mice induced by herpes simplex virus type 1 could be suppressed by the inhibitor of iNOS [133]. The issue of whether NO acts as an inhibitor of viral replication or as a harmful agent, therefore, remains unanswered. This issue is particularly evident in HIV-1 infection, since NO seems to act as a double-edged sword in the pathogenesis of HIV-1. 

S. B. (1987) Pathogenesis of bronchiolitis and pneumonia induced in neonatal and weanling rats by parainfluenza (Sendai) virus. Am. J. Pathol. 129, 227-286. 

Prince GA, Porter DD, Jenson AB, Horswood RL, Chanock RM, Ginsberg HS. Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). J Virol 1993 67 101-11. 

Meli DN, Christen S, Leib SL, Tauber MG. Current concepts in the pathogenesis of meningitis caused by Streptococcus pneumoniae. Cunt Opin Infect Dis 2002 15 253-257. 

Estes RJ, Meduri GU. The pathogenesis of ventilator-associated pneumonia I. Mechanisms of bacterial transcolonization and airway inoculation. Intensive Care Med 1995 21 365-383. 

Kurahashi K, Kajikawa O, Sawa T, et al. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J CUn Invest 1999 104 743-750. 

Tang HB, DiMango E, Bryan R, Gambello M, Iglewski BH, Goldgerg JB, Prince A. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect Immun 1996 64 37-43. 

Cytomegalovirus (CMV) is a ubiquitous beta-herpesvirus that has the distinguishing characteristic of all herpesviruses, the ability to persist in the host. Persistent CMV causes serious infections such as interstitial pneumonia, gastrointestinal mucosal ulceration, retinitis, and hepatitis in immunosuppressed patients. Elucidating mechanisms of CMV persistence is critical to a complete model of pathogenesis as CMV infection, morbidity, and mortality often are the result of dissemination of virus acquired before the onset of immunosuppression. 

Ginsberg HS, Moldawer LL, Sehgal PB, Redington M, Kilian PL, Chanock RM. Prince GA (1991) A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc Natl Acad Sci USA 88 1651-1655... 

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