Platelet kinetics

Shulman NR, Jordan JV Jr. Platelet kinetics. In Colman RW, Hirsh J, Marder VJ, Saltzman EW, eds. Hemostasis and Thrombosis. Basic Principles and ainical Practice, 2nd ed. Philadelphia, JP Lippincott, 1987 341-351. 

Letter MG, Heyns AD, Badenhorst PN et al (1987) Evaluation of mathematic models to assess platelet kinetics. J Nucl Med 27 1192-1201... 

Najean Y (1986) The choice of tracer for platelet kinetics and scintigraphic studies. Nucl Med Biol 13 159-164... 

Uchida T, Nemoto T, Yui T et al (1979) Use of technetium-99m as a radioactive label to study migratory patterns of leukocytes. J Nucl Med 20 1197-2000 Vallabhajosula S, Machac J, Goldsmith SJ et al (1986) Indium platelet kinetics in normal human subjects tropolone versus oxine methods. J Nucl Med 27 1669-1674... 

Our experimental model continuously evaluates net platelet accumulation, not necessarily thrombus growth and dissolution. These platelet kinetics are very unusual (see Figure 2) ... 

Ginsburg, A.D., Aster, R.H., 1973-1974. Discrepant platelet kinetic data obtained in rats using the platelet labels Cr and [ H]DFP. Haemostasis 2 (6),... 

Hay CRM, Durber AP, Saynor R (1982) Effect of flsh oil on platelet kinetics in patients with ischaemic heart disease. Lancet 1 1269-1272... 

Lie WJ, Homburg CH, Kuijpers TW, Knol EF, Mul FR Roos D, Tool AT Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. Clin Exp Allergy 2003 33 1125-1134. 

The nature of the nucleation site as well as the kinetics of formation and dissociation of the H-induced and stabilized platelets have yet to be experimentally studied in detail. However, their generation in float-zone (Johnson and Herring, 1988b) as well as Czochralski-grown (Fig. 8) silicon argues against the involvement of oxygen or carbon in platelet nucleation. 

In addition to the generation of platelets, hydrogenation of silicon also induces electronic deep levels in the band gap. As in the case of platelet formation, these defects are considered to be unrelated to either plasma or radiation damage because they can be introduced with a remote hydrogen plasma. Comparison of depth distributions and annealing kinetics of the platelets and gap states has been used to a limited extent to probe the relationship among these manifestations of H-induced defects. 

Ouimet, H., Freeman, J. E., and Loscalzo, J., Kinetics and mechanism of platelet surface plasminogen activity by tissue plasminogen activator. Biochem. 33, 2970-2976 (1994). 

Enzymatic kinetic resolution is a key step in the synthesis of the platelet aggregation inhibitor Lotrafiban (Figure 10.11). A disclosed process involves CaLB in tert-butyl alcohol/water (88 12) at 50 °C the substrate concentration was only r> g I 1 owing to its low solubility in this medium [122]. By exploiting the higher solubility in 88% [BMIm][PF6] and the better thermal stability of the biocatalyst in this medium, a higher rate was observed, the reaction was performed at 40 54 1. 1 at 75 °C, and the biocatalyst (Novozym 435) could be recycled 10 times. 

Lam, S.C.T. Packham, M.A. Isolation and kinetic studies of nucleoside diphosphokinase from human platelets and effects of cAMP phosphodiesterase inhibitors. Biochem. Pharmacol., 35, 4449-4455 (1986)... 

A quantitative indication of the importance of the cAMP system within cells can be derived from measurement of the kinetics of the incorporation of lsO from water into the a-phospho groups of AMP, ADP, and ATP. This incorporation will result from hydrolysis of cAMP by the phosphodiesterases that allow relaxation to a low cAMP level (Eq. 11-8). It is thought that in human blood platelets this represents the major pathway of this labeling (Eq. 11-9), which occurs at a rate of about 1.1 prnol of lsO kg s . 

Pederson, A.K. and G.A, FitzGerald Dose-Related Kinetics of Aspirin Presystemic Acetylation of Platelet Cyclooxygenase, N. Eng. J. Med., 1206 (November 6, 1984). 

Bundgaard, H. and M. Johansen. 1982. Kinetics of hydrolysis of tpHiaJe (An ureid J-Mannich base with platelet antiaggregant activity) in aqueous solution and in plasfon ]. Pharm. Chem., Sci. Ed. 10 139-145. 

The compounds potently inhibit factor Xa in vitro with reversible binding kinetics and are able to inhibit not only free but also prothrombinase-bound factor Xa (Ki 41 nM, 0.1 I nM, and 0,5 nM, respectively) (58-60), In contrast, no direct effect on platelet aggregation has been described (60-62), Antithrombotic activity in arterial and venous thrombosis models has been demonstrated and it has a reduced effect on hemorrhage in comparison to standard therapy (58,60,63). Factor Xa inhibitors are able to reduce the endogenous thrombin potential in platelet-poor as well as in platelet-rich plasma (64,65). Thus, thrombin generation seems to be a suitable biomarker for clinical evaluation and has been evaluated in phase I studies (66,67). 

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