Hetero Diels-Alder-biocatalysis approach

Hetero Diels-Alder-Biocatalysis approach for the synthesis of (S)-3- 2-[(methyl-sulfonyl) oxy]ethoxy -4-(triphenylmeth-oxy)-l-butanol methanesulfo-nate successful application of an enzyme resolution process Multi-kilo resolution of XU305, a key intermediate to the platelet glycoprotein Ilb/IIIa receptor antagonist roxifiban via kinetic and dynamic enzymatic resolution... 

Hetero Diels-Alder-Biocatalysis Approach for the Synthesis of (S)-3-[2- (Methylsulfonyl)oxy ethoxy]-4-(triphenylmethoxy)-1-butanol Methanesulfonate ... 

S0 I 3 Hetero Diels-Alder-Biocatalysis Approach Successful Application of an Enzyme Resolution Process... 

Our proposed synthesis of 1 using a hetero Diels-Alder-biocatalysis approach is shown in Fig. 4. In this study, we report the details of the development of a commercially viable process to make 1 based on the enzyme resolution of (R,S) 4 [12]. 

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See also in sourсe #XX -- [ ]

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