Deposition platelets

Platelet attachment to subendotheliumf is determined predominantly by physical factors controlling the rate of platelet transport to the subendothelium at low shear rates (800 s ). In addition, platelet deposition was found to be highly dependent on the concentration of red cells, an effect attributed in part to the fact that red cells, by increasing the radial movement of platelets, enhance their diffusivity by several orders of magnitude compared to that theoretically predicted and experimentally measured in platelet-rich plasma. 

Weiss et al. [10] have shown that platelet deposition is at a minimum at a shear rate of 50 s while fibrin deposition on subendothelium from non-anticoagulated blood is at a maximum at the same shear rate. At low shear rates (250 s ), fibrin... 

The effect of carboxylate and/or sulfonate ion incorporation on the physical and blood contacting properties of polyurethanes was studied by Cooper and collaborators [476-478]. Specifically, propyl sulfonate and ethyl carboxylate groups were grafted onto polytetramethylene oxide-based polyurethanes. Carboxylate polymers had no statistically significant effect on canine ex vivo blood contact response, but propyl sulfonate incorporation significantly reduced platelet deposition for very short blood contact times. 

Schersten F Wahlund G, Bjomheden T, et al. Melagatran attenuates fibrin and platelet deposition in a porcine coronary artery over-stretch injury model. Blood Coagul Fibrinolysis 2003 14 235-241. 

Foo RS, Hogrefe K, Baron JH, et al. Activated protein C eluting stent inhibits platelet deposition in an in vivo model [abstr]. Eur Heart J 1999 20(suppl) 367. 

Chronos N, Robinson K, White D, et al. Heparin coating dramatically reduces platelet deposition on incompletely deployed Plamaz-Schatz in the baboon A-V shunt [abstr]. J Am Coll Cardiol 1996 27 84A. 

Jeong M, Owen W, Staab M, et al. Does heparin release coating of the Wallstent limit thrombosis and platelet deposition Results in a porcine carotid injury model [abstr]. Circulation 1995 92 1-37. 

Chronos N, Robinson K, Kelly A, et al. Thrombogenicity of tantalum stents is decreased by surface heparin bonding scintigraphy of 111 In-platelet deposition in baboon carotid arteries. Circulation 1995 92 1-490. 

Tanguay JF Santos RM, Kruse KR, et al. Local delivery of a potent GPIIb/llla inhibitor using a composite polymeric stent reduces platelet deposition [abstr], Eur Heart J 1996 ... 

Santos RM, Tanguay JE Crowley JJ, etal, Local administration of L-703,08l using a composite polymeric stent reduces platelet deposition in canine coronary arteries, Am J Cardiol 1998 82(5) 673—675.A8. 

Kruse KR, Crowley JJ, Tanguay JE et al, Local drug delivery of argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model, Catheter Cardiovasc Interv 1999 46(4) 503-507,... 

Badimon JJ, Ortiz Ap Meyer B, et al, Different response to balloon angioplasty of carotid and coronary arteries effects on acute platelet deposition and intimal thickening, Atherosclerosis 1998 140(2)307-314. 

Lyle EM, Fujita T, Conner MW et al. (1995) Effect of inhibitors of factor Xa or platelet adhesion, heparin, and aspirin on platelet deposition in an atherosclerotic rabbit model of angioplasty injury. J Pharmacol Toxicol Meth 33 53-61 Meng K (1975) Tierexperimentelle Untersuchungen zur an-tithrombotischen Wirkung von Acetylsalicylsaure. Therap Ber 47 69-79... 

In contrast, identical Teflon grafts treated with a plasma polymer based on (hexafluoroethane + H2) showed markedly reduced platelet deposition over 1 h... 

Platelets patticipate in hemostasis and thrombosis by accumulating at sites of blood vessel injury (1). Platelet deposition at these sites is important for the physiologic arrest of... 

The deposition of fibrin on the subendothelium is inversely correlated with the shear rate [56]. Although less fibrin would be locally deposited at higher flow rates [52], thrombin would still be generated, fecilitating platelet deposition and growth of platelet aggregates at both low or high shear rates [57-59]. 

In this section, we will summarize the present knowledge of major adhesive proteins present in plasma and the subendothelium, which may play a role in mediating platelet deposition under flow conditions. 

A role for vitronectin in mediating platelet adhesion and thrombus formation is less clear. Collins et al [100] reported that vitronectin adsorbed on various polymers increased platelet deposition in a canine ex vivo model. However, antibodies either to vitronectin or to the specific platelet vitronectin receptor (a b,) did not decrease platelet adhesion or thrombus formation in citrated blood at any ear rate. 

GoMmanM, HallC, DykesJ, Hawker RJ, McCollum CN Does II 1-indium platelet deposition predict patency in prosthetic arterial grafts Brit. J. Surg. 635,1983... 

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