Platelet activating factor, neutrophil

Mast cell degranulation in response to allergens results in release of mediators such as histamine eosinophil, and neutrophil chemotactic factors leukotrienes C4, D4, and E4 prostaglandins and platelet-activating factor (PAF). Histamine is capable of inducing smooth muscle constriction and bronchospasm and may play a role in mucosal edema and mucus secretion. 

Lewis, M. S. et al., Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion, J. Clin. Invest. 82, 2045-2055, 1988. 

Schmidt, H. H. H. W., Seifert, R., Bohme, E. (1989). Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. FEBS Lett. 244, 357-60. 

Kurihara K, Wardlaw AJ, Moqbel R, Kay AB. (1989). Inhibition of platelet-activating factor (PAF)-induced chemotaxis and PAF binding to human eosinophils and neutrophils by the specific ginkgolide-derived PAF antagonist, BN 52021. J Allergy Clin Immunol. 83(1) 83-90. 

Smiley, P.L., Stremler, K.E., Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M., 1991, Oxidatively fragmented phosphatidylcholines activate human neutrophils trough the receptor for platelet-activating factor,/. Sioi. Chem. 266 11104-11110. 

Weber C, Springer TA. Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alpha Ilb beta 3 and stimulated by platelet-activating factor. J Clin Invest 1997 100 2085-2093. 

Paubert-Braquet, M., Longchampt, M.O., Koltz, P., and Gutlbaud, J. 1988. Tumor necrosis factor (TNF) primes human neutrophil (PMN) platelet-activating factor (PAF)-induced superoxide generation. Consequences in promoting PMn-mediated endothelial cell (EC) damages (abstract). Prostaglandins 35, 803. 

FI Naraba, Y Imai, I Kudo, Y Nakagawa, S Oh-ishi. Activation of phospholipase A2 and acylation of lysophospholipids the major regulators for platelet activating factor production in rat neutrophils. J Biochem (Tokyo) 118 442-447, 1995. 

Mueller, H. W., O Flaherty, J. T., and Wykle, R. L. (1984) The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils, J. Biol. Chem. 259, 14554-14559. 

Platelet activating factor is a phospholipid-derived signalling compound generated in animal systems by stimulated neutrophils, basophils, platelets and endothelial cells. PAF receptors... 

Nick, J. A., Avdi, N. J., Young, S. K., Knall, G., Gerwins, P., Johnson, G. L., and Worthen, G. S. (1997). Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J. Clin. Invest. 99, 975-986. 

Rediske, J. J., Quintavalla, J. C., Hasten, W. O., Morrissey, M. M., and Seligman, B. (1992). Platelet activating factor stimulates intracellular calcium transients in human neutrophils Involvement of endogenous 5-lipoxygenase products. J. Leukoc. Biol. 51, 484-489. 

Histamine, platelet-activating factor, leukotrienes (C4, D4, E4), prostaglandin D2, neutral proteases Histamine, platelet-activating factor, leukotrienes, prostaglandin Cytokines (chemokines and TNE), leukotriene B4, chemotactic factors for neutrophils and eosinophils... 

Thom, S.R., Fisher, D., Manevich, Y. (2001). Role of platelet activating factor and NO-derived oxidants causing neutrophils adherence after CO poisoning. Am. J. Physiol. 281 H923-30. 

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