Plasma treatments interactions possible

Bhat et al. (2011) report that the amount of dye absorbed depends on the time of plasma treatment. For the reactive dye, there are two SOj groups at the benzene ring, and these groups can bond at the OH site by abstraction of H due to plasma interaction. On prolonged exposure to plasma, additional sites of are created where dye molecules can interact and dyeing is enhanced. Although no direct proof of these suggested interactions currently exists, its seans to be a possibility. Additional experiments are planned. 

The use of two or more agents concurrently has the potential for possibly deleterious drug interactions. Thus, as noted in subsequent chapters, the addition or elimination of an agent may significantly alter the activity of the concurrent drug treatment (e.g., carbamazepine lowering haloperidol plasma levels nefazodone increasing the levels of triazolam). 

Luminous vapor treatment without depositing film (LGT) could be used to modify the surface characteristics of membranes. Type B plasma polymer also could be used for this purpose. General schemes of membrane application of LGT and LCVD are schematically depicted in Figures 34.2 and 34.3, respectively [2]. Since the luminous gas interacts with the substrate material, the selection of the membrane material and the gas to be used in these possible schemes is important, and it should not be considered that any combinations of gas and material could be used in any mode of application. 

More complicated isobolograms exist. The N-acetyl cysteamine dosage algorithm is an isobologram with time and acetaminophen (paracetamol) plasma concentration on the axes in the plane of the paper and a two-step measure in the third dimension (probability of toxicity that requires treatment). Somewhat as famous is Professor Herxheimer s depiction of the interaction between coffee and wine two glasses of each provide the maximum possible beneficial effect (the effect being happiness ). The contours are thus of a hill on a plane. 

Colmenero, J.D. Ferndndez-Gallardo, L.C. Agundez, J.A.G. Sedeno, J. Benitez, J. Valverde, E. Possible implications of doxycycline-rifampin interaction for treatment of brucellosis. Antimicrob.Agents Chemother., 1994, 38, 2798-2802 [extracted rifampin plasma serum papaverine (IS) LOQ 200 n mL]... 

Information seems to be limited but the pharmacokinetic interaction would appear to be established. Just how much it affects the outcome of treatment for systemic worm infections such as cysticercosis is unknown because the optimum praziquantel levels are still uncertain, and it is possible that the metabolites of praziquantel might be active. The authors of one report suggest that dexamethasone should not be given continuously with praziquantel but only used transiently to resolve inflammatory reactions to praziquantel treatment. Alternatively, limited information suggests the addition of cimetidine may allow dexamethasone to be used. Intravenous methylprednisolone has also been used for acute corticosteroid therapy with praziquantel, and oral prednisone has been used longterm to prevent further tissue damage associated with inflammation but the effect of these corticosteroids on the plasma levels of praziquantel do not appear to have been studied. 

---