Plasma membrane calcium pumps

Axelband F, Assungao-Miranda I, de Paula IR, Ferrao FM, Dias J, Miranda A, Miranda F, Lara LS, Vieyra A. (2009) Ang-(3 ) suppresses inhibition of renal plasma membrane calcium pump by Ang II. Regul Pept 155 81-90. 

Upon binding calcium ions, the small acidic protein known as calmodulin can activate enzymes by binding to a wide variety of proteins containing cahnodulin-binding domains. Such proteins include cAMP phosphodiesterase, calmodulin-dependent nitric oxide synthase, calmodulin kinases, the plasma membrane calcium pump, calcineurin, and calmodulin-dependent inositol-(l,4,5)-trisphosphate 3-kinase. See also Activation Autoinhibition... 

Hilfiker, H., Strehler-Page, M.A., Stauffer, T.P., Carafoli, E., Strehler, E.E., 1993, Structure of the gene encoding the human plasma membrane calcium pump isoform 1. J Biol Chem 268, 19717-19725. 

Lee, W.J., Roberts-Thomson, S.J., Holman, N.A., May, F.J., Lehrbach, G.M., Monteith, G.R., 2002, Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines. Cell Signal 14, 1015-1022. 

Oceandy, D., Buch, M.H., Cartwright, E.J., Neyses, L., 2006, The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease. Mini Rev Med Chem 6, 583-588. 

Padanyi, R., Paszty, K., Penheiter, A.R., Filoteo, A.G., Penniston, J.T., Enyedi, A., 2003, Intramolecular interactions of the regulatory region with the catalytic core in the plasma membrane calcium pump. J Biol Chem 278, 35798-35804. 

Strehler, E.E., Zacharias, D.A., 2001, Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev 81, 21—50. 

Sorin, A., Rosas, G., and Rao, R., 1997, PMR1, a Ca2+-ATPase in yeast Golgi, has properties distinct from sarco/endoplasmic reticulum and plasma membrane calcium pumps. J. Biol. Chem. 272, 9895-9901... 

Garrahan, P.J. Rega, A.F. (1990). Plasma Membrane Calcium Pump In Intracellular Calcium Regulation (Bronner, F., ed.), pp. 271-303, Alan R. Liss, Inc., New York. 

R. N. Reusch, R. P. Huang and D. Koskkosicka (1997). Novel components and enzymatic activities of the human erythrocyte plasma membrane calcium pump. FEBS Lett., 412, 592-596. 

The information derived from the analysis of this example was used as distance restraints for calculation of the 3D structure of the complex of calmodulin, a calcium binding protein, and a peptide ligand. The amino acid sequence of the peptide ligand, C20W, corresponds to the N-terminal part of the calmodulin-binding domain of the plasma membrane calcium pump (125). 

If different cells use calcium from different sources to mediate secretion, then it is likely that methods for removal of cytoplasmic calcium also vary. A plasma membrane calcium pump is important in adrenal medulla to extrude mediator calcium (22). In exocrine pancreas, calcium may be returned to intracellular storage pools, as well as extruded from the cell to terminate secretion. 

Thus, mast cells and basophils (26,45,46) appear to have a mechanism for limiting calcium entry into the cell which follows the cross-linking membrane signal. It is presumed that calcium already entered is removed from the intracellular site of action by mitochondria (47,48) or a plasma-membrane calcium pump (48). 

Schatzmann HJ (1982) The plasma membrane calcium pump of erythrocytes and other animal cells. In Carafoli E (ed) Membrane transport of calcium. Academic, New York, pp 41-108... 

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