Isoform diversity

Baba-Aissa F, Raeymaekers L, Wuytack F, Dode L, Casteels R. (1998). Distribution and isoform diversity of the organellar Ca2+ pumps in the brain. Mol Chem Neuropathol. 33(3) 199-208. 

Strehler, E.E., Zacharias, D.A., 2001, Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev 81, 21—50. 

Lees-Miller, J. P., and Helfman, D. M. (1991). The molecular basis for tropomyosin isoform diversity. Bioessays 13, 429-437. 

C. Touriol, S. Bomes, S. Bonnal, S. Audigier, H. Prats, A.C. Prats, and S. Vagner, Generation of protein isoform diversity by alternative initiation of translation at non-AUG codons, Biol Cell 95, 169-178 (2003). 

What is the reason for actin isoform diversity in smooth muscle ... 

III. ISOFORM DIVERSITY OF SKELETAL AND SMOOTH MUSCLE TROPOMYOSINS... 

The isoform diversity in striated muscles and their electrophoretic gel patterns are further complicated by partial phosphorylation of serine 283, the penultimate COOH-terminal residue (Ribolow and Barany, 1977 Mak etal., 1978 Montarras cfal., 1981,1982 Heeley cf al., 1982,1985). The extent of phosphorylation is highest for the a isoform in embryonic and neonatal tissue, dropping to much lower levels in adult muscle. Heeley et al. (1982,1989) and Heeley (1994) have compared the phosphorylated and nonphosphorylated forms of rabbit skeletal aa TM and observed significant differences... 

It is beyond the scope of this chapter to overview the complex isoform diversity generated by alternative splicing of the primary transcripts of the four recognized PMCA genes. The isoform diversity has been updated and reviewed by Carafoli (1994). The following is intended to represent the most essential information. 

Babij P, Periasamy M (1989) Myosin heavy chain isoform diversity in smooth musde is produced by differential RNA processing. J Mol Biol 210 673-679 Bagby RM (1990) Ultrastructure, cytochemistry, and organization of myofilaments in vertebrate smooth musde cells. In Motta PM (ed) Ultrastructure of Smooth Musde. Kluwer Academic Publishers, Boston, pp 23-61 Balint M, Sreter FA, Wolf I, Nagy B, Gergely J (1975) The substructure of heavy meromyosin. The effect of Ca and Mg " on the tryptic fragmentation of heavy meromyosin. J Biol Chem 250 6168-6177... 

White S, Martin AF, Periasamy M (1993) Identification of a novel smooth muscle myosin heavy chain cDNA isoform diversity in the SI head region. Am J Physiol 264 C12528... 

Kelley CA, Adelstein RS (1994) Characterization of isoform diversity in smooth muscle myosin heavy chains. Can J Physiol Pharmacol 72 1351-1360... 

Babij P, Periasamy M (1989) Myosin heavy chain isoform diversity in smooth muscle is produced by differential RNA processing. J Mol Biol 210 673-679... 

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