Plant isoprenoids biosynthesis

ZEIDLER, J., SCHWENDER, J., MULLER, C WIESNER, J., WEIDEMEYER, C., BECK, E., JOMAA, H., LICHTENTHALER, H.K., Inhibition of the non-mevalonate 1-deoxy-D-xylulose 5-phosphate pathway of plant isoprenoid biosynthesis by fosmidomycin, Z. Naturforsch., 1998,53c, 980-986. 

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Hsieh, M.H. and Goodman, H.M., The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis, Plant Physiol. 138, 641, 2005. 

Walter, M.H., Fester, T., and Strack, D., Arbuscular mycorrhizal fungi induce the non-mevalonate methylerythritol phosphate pathway of isoprenoid biosynthesis correlated with accumulation of the yellow pigment and other apocarotenoids. Plant J. 21, 571, 2000. 

Estevez, J.M. et al., l-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants, J. Biol. Chem. 276, 22901, 2001. 

LANGE, B.M., CROTEAU, R., Isoprenoid biosynthesis via a mevalonate-independent pathway in plants cloning and heterologous expression of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from peppermint, Arch. Biochem. Biophys., 1999,365,170-174. 

Lichtenthaler HK, Rohmer M, Schwender J (1997) Two independent biochemical pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants. Physiol Plantarum... 

C-methyl-D-erythritol 2,4-cyclodiphosphate synthase catalyses the conversion of 4-diphospho-cytidyl-2-C-methyl-D-erythritol 2-phosphate to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) (Equation (7)). This reaction is part of the isoprenoid biosynthesis pathway in many plants and bacteria. The structure of the E. coli enzyme bound to Mn, cytosine monophosphate, and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate has been determined. The enzyme in the crystal and probably in solution is trimeric, three monomers are packed in a circular assembly with three-fold symmetry. The active site is at the interface of two adjacent monomers all the ligands bound to the Mn + come from one monomer and a MECDP molecule. The structure of this active site is shown in Figure 29 ... 

SCHEME 1.—The Biosynthesis and Metabolism of Dolichyl Phosphate and Other Plant Isoprenoids. 

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Phillips, M.A., D Auria, J.C., Gershenzon, J. and Pichersky, E. (2008) The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple sub-cellular compartments and have overlapping functions in isoprenoid biosynthesis. Plant Cell, 20, 677-96. 

Seemann M, Tse Sum Bui B, Wolff M, Miginiac-Maslow M Rohmer M. isoprenoid biosynthesis in plant chloroplasts via the MEP pathway direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG. FEBS Lett. 2006 580 1547-1552. 

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