Pathways methylerythritol phosphate

Rodriguez-Concepcion, M. and Boronat, A., Elncidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in hacteria and plastids a metabolic milestone achieved throngh genomics. Plant Physiol. 130, 1079, 2002. Rodriguez-Concepcion, M., Early steps in isoprenoid biosynthesis multilevel regulation of the supply of common precursors in plant cells, Phytochem. Rev. 5, 1, 2006. Eisenreich, W., Rohdich, F., and Bacher, A., Deoxyxylulose phosphate pathway to terpenoids, Trends Plant Sci. 6, 78, 2001. 

Hampel, D., Mosandl, A., and Wust, M., Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.) metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways, Phytochemistry 66, 305, 2005. 

Walter, M.H., Fester, T., and Strack, D., Arbuscular mycorrhizal fungi induce the non-mevalonate methylerythritol phosphate pathway of isoprenoid biosynthesis correlated with accumulation of the yellow pigment and other apocarotenoids. Plant J. 21, 571, 2000. 

Walter, M. H., D. S. Flo et al. (2007). Apocarotenoid biosynthesis in arbuscular mycorrhizal roots Contributions from methylerythritol phosphate pathway isogenes and tools for its manipulation. 

Plant metabolism can be separated into primary pathways that are found in all cells and deal with manipulating a uniform group of basic compounds, and secondary pathways that occur in specialized cells and produce a wide variety of unique compounds. The primary pathways deal with the metabolism of carbohydrates, lipids, proteins, and nucleic acids and act through the many-step reactions of glycolysis, the tricarboxylic acid cycle, the pentose phosphate shunt, and lipid, protein, and nucleic acid biosynthesis. In contrast, the secondary metabolites (e.g., terpenes, alkaloids, phenylpropanoids, lignin, flavonoids, coumarins, and related compounds) are produced by the shikimic, malonic, and mevalonic acid pathways, and the methylerythritol phosphate pathway (Fig. 3.1). This chapter concentrates on the synthesis and metabolism of phenolic compounds and on how the activities of these pathways and the compounds produced affect product quality. 

Rohmer M (2007) Diversity in isoprene unit biosynthesis the methylerythritol phosphate pathway in bacteria and plastids. Pure Appl Chem 79 739-751... 

Keeling PJ, Burger G, Dumford DG, Lang BF, Lee RW, Pearlman RE, Roger AJ, Gray MW (2005) The tree of eukaryotes. Trends Ecol Evol 20 670-676 Kim D, Filtz MR, Proteau PJ (2004) The methylerythritol phosphate pathway contributes to carotenoid but not phytol biosynthesis in Euglena gracilis. J Nat Prod 67 1067-1069... 

Colonization of barley, wheat and maize and rice roots by Glomus intraradices resulted in strong induction of transcript levels of the pivotal enzymes of methylerythritol phosphate pathway of isoprenoid biosynthes i.e., 1 -deoxy-D-xylulose 5-phosphate synthase (DXS) and 1 -deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (Walter et al., 2000). At the same time six cyclohexenone derivatives were characterized from mycorrhizal wheat and maize roots. DXS2 transcript levels are low in most tissues but are strongly stimulated in roots upon colonization by mycorrhizal fungi, correlated with accumulation of carotenoids and apocarotenoids (Walter et al., 2002). Some reports show that the AM symbiosis may cause an increase, decrease, or no change in the plant defense reactions (Guenoune et al., 2001 Mohr et al., 1998). 

Keywords biosynthesis genes monoterpenes sesquiterpenes diterpenes mevalonate pathway methylerythritol phosphate pathway... 

Rohmer, M. (2008) From molecular fossils of bacterial hopanoids to the formation of isoprene units discovery and elucidation of the methylerythritol phosphate pathway. Lipids, 43,1095-107. 

Methylerythritol Phosphate Pathway for the Formation of Isoprene Units... 

Seemann M, Rohmer M. Isoprenoid biosynthesis via the methylerythritol phosphate pathway GcpE and LytB, two novel iron/ sulphur proteins. C.R. Chimie 2007. In press. 

Hemmerlin A, Hoeffler JF, Meyer O, Tritsch D, Kagan lA, Grosdemange-Billiard C, Rohmer M, Bach TJ. Cross-talk between cytosolic mevalonate and plastidial methylerythritol phosphate pathways in tobacco Bright Yellow-2 cells. 1. Biol. Chem. 2003 278 26666-26676. 

Kim D, Eiltz MR, Protean PJ. The methylerythritol phosphate pathway contributes to carotenoid but not phytol biosynthesis in Euglena gracilis. J. Nat. Prod. 2004 67 1067-1069. 

Lherbet C, Pojer F, Richard SB, Noel JP, Poulter CD. Absence of substrate channeling between active sites in the Agrobacterium tume-faciens IspDF and IspE enzymes of the methylerythritol phosphate pathway. Biochemistry 2006 45 3548-3553. 

The compound (54) has been enzymatically converted into a phosphorylated derivative of (E)-2-methylbut-2-ene-l,4-diol, which most probably represents a novel intermediate in the methylerythritol phosphate pathway of isoprenoid biosynthesis. The use of a photolabile acetal protecting group enables the synthesis of glycoaldehyde di-, and triphosphates (55) and (56) respectively. 

Rodriguez-Concepcion M. and A. Boronat Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiol. 130(2002) 1079-1089. 

E. coli and other Gram-negative bacteria synthesize the IPP and dimethylallyl diphosphate (DMAPP) by the mevalonate-independent pathway, also known as the nonmevalonate pathway (other names are deoxyxylulose phosphate or methylerythritol phosphate pathway). In contrast. Gram-positive bacteria and eukaryotes, including yeast, synthesize the side chain precursors by the mevalonate pathway. Interestingly, Streptomycetes possess both the mevalonate and nonmevalonate pathways. These pathways are the subject of Chapters 1.12, 1.13, 1.14, 1.22. 

Processes affecting the carbon-isotopic compositions of isoprenoid lipids. The isoprene carbon skeleton is indicated schematically in Figure 27. The corresponding biosynthetic reactant—equivalent in its role to acetyl-CoA—is isopentenyl pyrophosphate. As shown in Figure 29, this compound can be made by two different and fully independent pathways. The mevalonic-acid pathway was until recently thought to be the only route to isoprenoids. The deoxyxylulose-phosphate, or methylerythritol-phosphate, pathway was first discovered in Bacteria by Rohmer and coworkers (Flesch and Rohmer... 

Kasahara H, Hanada A, Kuzuyama T, Takagi M, Kamiya Y, Yamaguchi S (2002) Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in arabidopsis. J Biol Chem 277 45188 5194... 

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