Plant antimicrobials shrimps

A series of acetate-derived compounds have been reported from plants of the family Annonaceae (Annona cherimolia, A. muricata, A. squamosa, and oth r Annona species Asim-ina triloba, pawpaw Goniothalamus giganteus , and several Rollinia and Uvaria species) (Fig. 5.20) (Alkofahi et al., 1989 Lieb et al., 1990 Nahrstedt, 1985 Rupprecht et al., 1986). Most of these compounds exhibit potent antimicrobial, antiparasitic, cytotoxic, and antitumor activity (Bories et al., 1991). For example, asimicin (36), from the bark of Asimina triloba, is extremely cytotoxic (ED50 <10 p-/ml with several cell cultures) fractionation of the plant material was monitored by the brine shrimp bioassay (Alkofahi et al., 1989). This compound also is toxic to the striped cucumber beetle, Mexican bean beetle, mosquito larvae, blowfly larvae, melon aphid, two spotted spider mite, and the free-living nematode, Caenorabditis elegans (Rupprecht et al., 1986). 

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