Plague isolation

Aikimbayev, A., Kisselev U., et al. The effect of human plague isolates on eukaryotic cells [Russian], The plague epidemiological surveillance and prophylaxis measures. Almaty Kazakhstan, 1992, pp. 45 18. 

Example A family of biologically active compounds Isolated from African trees include polygodial (39), an antifeedant which protects the tree against plagues of caterpillars. ... 

The synthesis reported by Paquette was plagued by several steps of very low stereoselectivity and is, at 26 steps, the longest of the four approaches. However, the analysis of the various stereoisomers related to retigeranic acid helped to finally end the confusion regarding the mixture of stereoisomers in the original isolate of retigeranic acid. 

The process requires vast amounts of solvent, proceeds in low yield, and is plagued by the need to isolate and handle a potentially explosive intermediate. 

Decontamination Soap and water, or diluted sodium hypochlorite solution (0.5 percent). Removal of potentially contaminated clothing should be done by people in full protective clothing in an area away from non-contaminated persons. For victims with bubonic plague, drainage, and secretion procedures need to be employed. Careful treatment of buboes is required to avoid aerosolizing infectious material. For victims with pneumonic plague, strict isolation is absolutely necessary. Heat, disinfectants and sunlight renders bacteria harmless. 

Isolation Precautions for Bubonic Plague Standard precautions for all aspects of care including strict hand washing with antimicrobial soap. 

Cleaning, Disinfecting Equipment with Pneumonic Plague (The same series of isolation controls as for bubonic plague). 

Second, we have to compare the rate of scientific progress in the AIDS epidemic with other epidemics that have had great impacts on society for example, the Black Death (plague) caused by Yersinia pestis. Plague caused a major epidemic in the fifth century and a second major epidemic in the fourteenth century. The infectious agent Yersina pestis was isolated in 1908. Effective therapy against the disease had to wait for the development of classical antibiotics in the 1940s. 

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