Pj-adrenergic receptors

The answer is b. (Katzung, p 166.) Propranol nonspecifically blocks pj-adrenergic receptors. It lowers blood pressure primarily by decreasing cardiac output... 

Benovic J Pj-Adrenergic receptor signaling pathways. J Allergy Clin Immunol 2002 110 S229-S235. 

The gene encoding the pj-adrenergic receptor displays a fair degree of polymorphism in the human population. Like the dopamine receptors, the p -adrenergic receptor variants are often relevant to pharmacogenetics. Constitutively active mutant (CAM) and loss-of-function (LOF) variants are in evidence. 

Pj-Adrenergic receptor G389R (C-terminus) t Basal and agonist-depend (152,257)... 

The classic example of an asthma pharmacogenetic candidate gene is ADRP2 (Pj-adrenergic receptor). The P -adrenergic receptor agonists, such as the short-acting... 

Daaka, Y., Luttrell, L.M., and Lefkowitz, R.J. (1997) Switching of the coupling of the Pj-adrenergic receptor to different G proteins hy protein kinase A. Nature 390 88-91. 

Fig. 8.1 Sequence alignment of the four hARs (A, A2a, A, A3), bovine rhodopsin, hp2 adrenergic receptor, and turkey pj adrenergic receptor. In grey are highlighted the transmembrane regions, in red the highly conserved residues and in yellow cysteines that form disulfide linkages that involve EL2. For Ar A2B, AjARs only the cysteine residues that form the conserved disulfide bridge between TM3 and EL2 are highlighted in yellow, because information about other disulfide bonds is not available...

Saffitz, J.E., and Liggett, S.B. 1992. Subcellular distribution of pj-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. Circ. Res. 70 1320-1325. 

Searles, R.P., Midson, C.N., Nipper, V.J., and Machida, C.A. 1995. Transcription of the rat Pj-adrenergic receptor gene. Characterization of the transcript and identification of important sequences. J. Biol. Chem. 270 157-162. 

Samama P, Cotecchia S, Costa T, Lefkowitz RJ. A mutation-induced activated state of the Pj-adrenergic receptor. Extending the ternary complex modd. J Biol Chem 1993 268 4625-36... 

Vauquelin G, Bottari S, KanarekL, Strosberg AD. Evidence for essential disulfide bonds in Pj-adrenergic receptors of turkey erythrocyte membranes. Inactivation by dithiothreitol. J Biol Chem 1979 254 4462-4469. 

Hu LYA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ. GIPC interacts with the Pj-adrenergic receptor and regulates p,-adrenergic receptor-mediated ERK activation. J Biol Chem 2003 278 26,295-26,301. 

Hu LA, Tang Y, Miller WE, et al. Pj-Adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of pradrenergic receptor interaction with IV-methyl-D-aspartate receptors. J Biol Chem 2000 275 38,659-38,666. 

Xiang Y, Devic E, Kobilka B. The PDZ binding motif of the Pj adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J Biol Chem 2002 277 33,783-33,790. 

Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning of the cDNA for the human Pj -adrenergic receptor. Proc Natl Acad SciUSA1987 84 7920-7924. 

Rohrer DK, Schauble EH, Desai KH, Kobilka BK, Bernstein D. Alterations in dynamic heart rate control in the Pj-adrenergic receptor knockout mouse. Am J Physiol 1998 274 H1184-H1193. 

Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ. G protein-coupled receptor kinase 5 regulates Pj-adrenergic receptor association with PSD-95. J Biol Chem 2002 277 1607-1613. 

Engelhardt S, Boknik P, Keller U, Neumann J, Lohse MJ, Hein L. Early impairment of calcium handling and altered expression of junction in hearts of mice overexpressing the Pj-adrenergic receptor. FASEB J 2001 15 2718-2720. 

Ungerer M, Bohm M, Elce JS, Erdmann E, Lohse ML. Altered expression of P-adrenergic receptor kinase and Pj-adrenergic receptors in the failing heart. Circulation 1993 87 454-463. 

Engelhardt S, Grimmer Y, Fan GH, Lohse MJ. Constitutive activity of the human Pj-adrenergic receptor in Pj-receptor transgenic mice. Mol Pharmacol 2001 60 712-771. 

Mason DA, Moore JD, Green SA, Liggett SB. A gain-of-function polymorphism in a G-protein coupling domain of the human Pj-adrenergic receptor. J Biol Chem 1999 274 12,670-12,674. 

Moore JD, Mason DA, Green SA, Hsu J, Liggett SB. Racial differences in the frequencies of cardiac Pj-adrenergic receptor polymorphisms analysis of cl45A>G and cll65G>C. Hum Mutat 1999 14 271. 

Wagoner LE, Craft LL, Zengel P, et al. Polymorphisms of the Pj-adrenergic receptor predict exercise capacity in heart failure. Am Heart J 2002 144 840-846. 

O-N 1,2,4-Oxadiazoles Pj adrenergic receptor agonist Fatty acid oxidation inhibitors Naylor et Feng et Biftu et Parmee et Elzein et Koltun et... 

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