Pituitary Growth Factor

Pituitary Growth Factor (from human pituitary giand) [336096-71-0]. Purified by heparin and copper affinity chromatography, followed by chromatography on carboxymethyl cellulose (Whatman 52). [Rowe et al. Biochemistry 25 6421 1986.]... 

Pituitary Growth Factor (from human pituitary gland) [336096-71-0], It is purified by heparin and copper... 

Human growth hormone (hGH) is a polypeptide with 191 amino acids. It is secreted by the pituitary gland. This hormone stimulates the production of insulin-like growth factor-1 (IGF-1) from the liver. Most of the positive effects of hGH are mediated by the IGF-1 system, which also includes specific binding proteins. 

Some other saponins have been reported to have a potentiation activity on the nerve growth factor [12], stimulate the pituitary-adrenocortical system [13], and saponins were recently shown to have favorable antitumorigenic effects [14, 15]. 

The Sertoli cells in the testis synthesize and secrete a variety of active proteins, including miillerian duct inhibitory factor, inhibin, and activin. As in the ovary, inhibin and activin appear to be the product of three genes that produce a common ot subunit and two subunits, A and B. Activin is composed of the two subunits ( ). There are two inhibins (A and B), which contain the a subunit and one of the subunits. Activin stimulates pituitary FSH release and is structurally similar to transforming growth factor-B, which also increases FSH. The inhibins in conjunction with testosterone and dihydrotestosterone are responsible for the feedback inhibition of pituitary FSH secretion. 

The pituitary growth hormone is only one of a large family of protein growth factors that are secreted by cells and which promote the growth of other cells.200 Many of the growth factors are also described as cytokines, local protein hormones that conduct cell-to-cell communication to regulate growth, development,... 

Ferrara N, Henzel WJ. 1989. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161 851-858. 

Growth hormone is a peptide hormone produced by the anterior pituitary. It produces growth at open epiphyses via stimulation of insulin-like growth factor I (IGF-I, somatomedin C). It also causes lipolysis in adipose tissue and growth of skeletal muscle. 

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