Pituitary adenoma growth hormone-secreting

Klingebiel R, Foisting M, Bruckmann H, Dorfler A, Jordan M, Buchfelder M, Knauth M. Tumor volume of growth hormone-secreting pituitary adenomas during treatment with pegvisomant a prospective multicenter study. J Clin Endocrinol Metab 2010 95(2) 552-8. 

The condition which results from excess growth hormone secretion in adults, the usual cause being a pituitary adenoma. The condition is characterized by increases in bulk of the bones and soft tissues, especially of the jaw, hands and feet. Because growth hormone is involved in glucose homeostasis, impaired glucose tolerance can occur. Acromegaly can be diagnosed biochemically by ... 

A condition that can result from excess growth hormone secretion in childhood usually from a pituitary adenoma. 

Fedele, M DeMartino, I., Pivonello, R., et al. (2007) SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas. Clin. Cancer Res. 13,2738-2744. 

From a pathological perspective, the detailed MS study of pituitary tumors can be used to determine whether proteins that regulate cell growth or hormone secretion are over- or under-expressed in neoplastic tissue, and whether they can be used as blood biomarkers of tumor mass and activity. For example, secreta-gogin, which is important for pancreatic 8-cell insulin secretion, is a newly discovered protein in the normal adenohypophysis it and its mRNA are underexpressed in null cell/gonadotroph pituitary adenomas [17]. Further studies are needed to determine whether secretagogin plays a physiological role in pituitary hormone secretion. 

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