Pipothiazine

Pipothiazine, Chlorprothixene, Haloperidol, Penfluridol, Clozapine, Sulpride, Thioridazine ... 

Fluphenazine decanoate, Pipothiazine palmitate, FFaloperidol decanoate, Flupenthixol decanoate, Clopenthixol decanoate Psychosis... 

Across the sites, an average of 15% of inpatients received depot antipsychotic drugs (Sim etal, 2004b). This was most common in Singapore (75%) followed by Taiwan (20%), Japan and China (6%). The depot antipsychotic drugs used were fluphenazine decanoate, flupenthixol decanoate, zuclopenthixol decanoate, haloperidol decanoate, pipothiazine palmitate, and fluphenazine enanthate. 

The piperidines, e.g. thioridazine, pipothiazine and pericyazine, have the lowest potential to cause extrapyramidal effects. Thioridazine is one of the most sedative phenothiazines. It may decrease the inotropic activity of digitalis by its quinidine-like action, which can cause myocardial depression, decreased efficiency of repolarization, and increased risk of tachyarrhythmias. With thioridazine drug induced sexual dysfunction and especially cardiotox-icity with prolongation of the QT-interval are more frequently seen than with other phenothiazines. For the above reasons thioridazine is withdrawn from the market in many countries. 

Infra-red Spectrum. Principal peaks at wavenumbers 1165,1735, 710, 745, 1250, 955 (pipothiazine palmitate, solution in carbon tetrachloride-carbon disulphide). 

Disposition in the Body. Pipothiazine palmitate is very slowly absorbed from the site of intramuscular injections and gradually releases pipothiazine into the body. After oral administration of pipothiazine, about 1% of a dose is excreted in the urine unchanged in 24 hours. 

Dose. Usually 10 to 20 mg of pipothiazine daily, by mouth. Pipothiazine palmitate is given intramuscularly in doses of 25 to 200 mg, at intervals of about 4 weeks. 

Carbetapentane Citrate 587.6 Diminazene Aceturate 714.1 Pipothiazine Palmitate... 

If antiparkinson agents are being used, they should be continued for a fe A/ A/eeks after pipothiazine is discontinued... 

Antacids, antiparkinson drugs, and iithium may reduce pipothiazine absorption... 

Haloperidol, zuclopenthixol, fluphenazine, flupentixol and pipothiazine are available as depot intramuscular injections for maintenance treatment of patients with schizophrenia and other chronic psychotic disorders. Provided the patient is willing to agree to have depot injections, usually by a community psychiatric nurse at intervals of 2-4 weeks, the need to take tablets two or three times a day is removed. Poor compliance with oral medication is the most common cause of admission to hospital with a relapse of schizophrenia. A reduced initial dose of the depot medication should be given, with a review for unwanted effects after 5-10 days. 

Labelalol Plasma Tranquillizers Pipothiazine Plasma, urine... 

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