Diminazene aceturate

Ultraviolet Spectrum. Diminazene aceturate aqueous acid— 257 nm (Al=305 a) aqueous alkali—247 nm (broad) (A = 239 b). 

Carbetapentane Citrate 587.6 Diminazene Aceturate 714.1 Pipothiazine Palmitate... 

Diminazene, 555 Diminazene aceturate, 555 Dimophebumine, xvii Dimorphone, 667 Dimotane, 403, 893, 895 Dimotapp, 403, 893, 895 Dimoxyline, 555 Dimoxylinephosphate, 555 Dimpylate, 528 Dimyril, 686 Dindevan, 880 Dinitolmide, 555 Dinitramine, 83 Dinitrocresol, 555 Dinitrol, 555... 

In horses, diminazene aceturate should be administered by deep i.m. injection divided between several injection sites. The injection sites should be massaged in order to promote drug absorption. At the dose rates suggested here, signs of toxicity are imcommon but local reactions, caused by muscle necrosis, may be severe. Diminazene aceturate should be avoided in horses unless other drugs are either ineffective or unavailable. Toxic doses result in respiratory distress, depression, cardiac signs, hypersalivation and diarrhea. Toxic doses may be treated with calcium salts. 

Diminazene aceturate is used for the treatment of T. brucei infections in horses and minimal resistance is reported (see Piroplasmosis, p. 51). However, it should only be used in horses when no other treatment is available because it produces severe local reactions (muscle necrosis). If diminazene aceturate is used, the dose should be divided into two or three portions administered 4h apart. 

Witola W H, et al. (2004). RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate. Exp. Para-sitol. 107(1-2) 47-57. 

P. O. Akpa, R. C. Ezeokonkwo, C. A. Eza and B. M. Anene, Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs, Vet. ParasitoL, 2008, 151, 139-149. 

Fl.-M. Kellner, FI. G. Eckert and M. FI. Volz, Studies in cattle of the antitrypanosomal drug Diminazene-aceturate (Berenil), Trop. Med. Para-sitoL, 1985, 36, 199-204. 

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