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Physiologically-based pharmacokinetic pharmacodynamic

Medinsky MA. 1995. The application of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling to understanding the mechanism of action of hazardous substances. Toxicol Lett 79 185-191. [Pg.218]

PoetTS, KousbaAA, Dennison SL, TimchalkC. 2004. Physiologically based pharmacokinetic/ pharmacodynamic model for the organophosphorus pesticide diazinon. Neurotoxicology 25 1013-1030. [Pg.257]

Physiologically Based Pharmacokinetic/ Pharmacodynamic Modeling of Countermeasures to Nerve Agents... [Pg.951]

CHAPTER 62 Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling... [Pg.953]

Yang RSH, el-Masri E1A, Thomas RS, Constan AA. The use of physiologically-based pharmacokinetic/pharmacodynamic dosimetry models for chemical mixtures. Toxicol Lett 1995 82-83 497-504. [Pg.66]

El-Masri HA, Thomas RS, Sabados GR, Phillips JK, Constan AA, Benjamin SA, et al. Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone. Arch Toxicol 1996 70 704-13. [Pg.67]

Doerge, D. R., Young, J. F., Chen, J. J., Dinovi, M. J., and Henry, S. H. (2008). Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity. J Agric Food Chem 56, 6031-6038. [Pg.581]

Zhang, X., Tsang, A. M., Okino, M. S., Power, F. W., Knaak, J. B., Harrison, L. S., and Dary, C. C. (2007). A physiologically based pharmacokinetic/pharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related dose estimating model. Toxicol Sci 100, 345-359. [Pg.612]

Yang, RS., el Masri, H.A., Thomas, R.S., Constan, A.A., and Tessari, J.D., 1995, The application of physiologically based pharmacokinetic/pharmacodynamic (PBPIC/PD) modeling for exploring risk assessment approaches of chemical mixtures, Toxicol. Lett., 19, 193-200. [Pg.112]

Poulin P, Burczynski FJ, Haddad S. 2015b. The role of extracellular binding proteins in the cellular uptake of drugs impact on quantitative in vitro-to-in vivo extrapolations of toxicity and efficacy in physiologically based pharmacokinetic-pharmacodynamic research. J. Pharm. Sci. 104. doi 10.1002/jps.24571. [Pg.80]

Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling has proven useful in many areas of toxicology and therapeutics. This quantitative, mechanism-based approach has allowed limited experimental in vivo and in vitro data to be quantitatively integrated with physiological data to facilitate predictions of the behavior of organisms under different exposure conditions. Specifically, it has been used for ... [Pg.1035]

PHYSIOLOGICALLY BASED PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF COUNTERMEASURES TO NERVE AGENTS... [Pg.1036]

T. S. Poet, A. A. Kousba, S. L. Dennison and C. Timchalk, Physiologically based pharmacokinetic/pharmacodynamic model for the organophos-phorus pesticide diazinon. Neurotoxicology, 2004,25,1013-1030. [Pg.107]

Modeling Organophosphortis Chemical Watfare Nerve Agents A Physiologically Based Pharmacokinetic-Pharmacodynamic (PBPK-PD) Model ofVX... [Pg.213]

See other pages where Physiologically-based pharmacokinetic pharmacodynamic is mentioned: [Pg.122]    [Pg.116]    [Pg.396]    [Pg.203]    [Pg.122]    [Pg.123]    [Pg.206]    [Pg.1]    [Pg.117]    [Pg.862]    [Pg.875]    [Pg.214]   


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