Physiologic considerations

Doses calculated in animals are converted to equivalent doses in humans on the basis of comparative physiological considerations (c.g., ventilatory parameters and regional lung surface areas). Additionally, if the e.xposure period was discontinuous, it is adjusted to reflect continuous e.xposure. 

II. PHYSIOLOGICAL CONSIDERATIONS FOR THE VARIOUS ROUTES AND PATHWAYS OF DRUG INPUT... 

J. G. Hall, The lymphatic system in drug targeting An overview, in Targeting of Drugs. Anatomical and Physiological Considerations (G. Gregoriadis and G. Poste, eds.), Plenum Press, New York, 1985, p. 15. 

Modern Delivery Strategies Physiological Considerations for Orally Administered Medications... 

Nagai, K. and Suda, T. (1986). Antineoplastic effects of carnosine and beta-alanine—Physiological considerations of its antineoplastic effects. Nippon Seirigaku Zasshi 48, 741-747. 

Moreover, combinations of these models can also be used to roughly describe physiological considerations. For instance, if the drug is metabolized by the liver and simultaneously eliminated by the kidney, a gamma profile is obtained as solution of (7.3), where the a/t term expresses the structural heterogeneity of the liver, and the term j3, the homogeneous elimination process from the kidney. 

CHALLENGES IN OCULAR DRUG DELIVERY 5.9.2.1 Anatomical and Physiological Considerations... 

PHYSIOLOGIC CONSIDERATIONS IN PEDIATRIC CARE FOLLOWING A DISASTER OR PUBLIC HEALTH EMERGENCY... 

American College of Radiology. (2002). Radiation disasters Preparedness and response for radiology. Reston, VA Author. Berger, M. E., Hurtado, R., Dunlap, J., Mutchinick, O., Valasco, M. G., Tostado, R. A., et al. (1997). Accidental radiation injury to the hand Anatomical and physiological consideration. Health Physics, 72(3), 343-348. 

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