Physiologic considerations inhibition/stimulation

Thyronine—receptor complexes stimulate or inhibit gene expression in almost every tissue in the human body, and therefore necessarily command our focus. The result is a thyroid hormone (TH)-centric perspective of iodine physiology that persuades us to avoid consideration of nonthyronine pharmacologic activity associated with iodine. The role for so-called extrathyroidal iodine has been discussed in the hterature as iodide uptake in the majority of breast cancers has aroused the interest of several researchers (Venturi et at. 

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