Photochemotherapy agents

Psoralen, or derivatives of 9-methoxy-7H-furo[3,2-g]chromen-7-one tricyclic ring structures, are used as photoreactive groups in crosslinkers, biotinylation compounds, and nucleic acid probes. Psoralens have been used for many years as photochemotherapy agents for treatment of psoriasis and vitiligo (Smith and Barker, 2006). Psoralens react when exposed to UV light... 

Finally these compounds may also present in the future some interest in the area of novel anti-tumor drugs, or in photochemotherapy [12], Up to now the mechanism of action of the Pt complexes as antineoplastic agents has been extensively examined [13]. In spite of their successful applications, there is a need in compounds that are less toxic than the Pt derivatives. Therefore novel photo-active metallic compounds could offer future possibilities for cancer treatment. The fact that a drug would become active exclusively under illumination might represent an advantage. 

Multiple pharmacotherapeutic approaches to psoriasis management include first-line therapy for mild to moderate psoriasis with topical agents. In severe psoriasis, photochemotherapy and... 

Sensitizers can be employed for agricultural purposes as herbicides and insecticides, or for medical purposes as antibacterial and antiviral agents. Moreover, sensitizer-based methods serve as tools for the analysis of the interaction faces of polymer complejKs and the sequence-selective photocleavage of double-stranded DNA. The ways in which photosensitized reactions are utilized are illustrated by the following typical examples. The first case relates to the photochemotherapy of cancer cells in superficial solid tumors [48]. The sophotodynamic therapy, PDT, is based on the selective incorporation of a photosensitizer into tumor cells, followed by exposure to light (commonly at A=600 nm). Cytotoxic products, namely singlet oxygen, O, and superoxide radical anions,... 

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