Phosphosphingolipid

Phospholipids (a) glyoerol backbone and phosphoglyoerols, (b) sphingosine backbone and phosphosphingolipids. 

Phosphosphingolipids Phosphonosphingolipids Neutral glycosphingolipids Acidic glycosphingolipids... 

Figure 1.6. Typical structures of sphingolipids (phosphosphingolipid and glycosphingolipid classes), based on a dl8 l ceramide (R = fatty acid group).

The primary hydroxyl group is substituted in one of two ways to give two classes of sphingolipid these are the phosphosphingolipids and glycosphingolipids. 

In phosphosphingolipids, the primary hydroxyl group is esterified with choline phosphate. The lipid is known as sphingomyelin. It has the structure ... 

Question Which of the following lipids are amphiphilic fatty acids acylate ions TAGS cholesterol phosphoglycerides phosphosphingolipids glycosphingolipids ... 

Membranes contain lipids, proteins, and small amounts of carbohydrate. The mass ratios of these vary considerably according to the type of membrane. The carbohydrate is present as glycoglycerolipid, glycosphingolipid, and glycoprotein. The most common types of lipid found in all membranes are phosphoglycerides and phosphosphingolipid (sphingomyelin). Cholesterol is found... 

The vitamin also activates serine palmitoyltransferase, the first enzyme of phosphosphingolipid synthesis, and in bacteria it can, together with inorganic phosphate, replace part of the ATP requirement of galactocerebroside sulfo-transferase (Tsaioun, 1999). In animals, lipid sulfatides are decreased in vitamin K deficiency and increased with higher intakes (Sundaram et al., 1996). 

The major subclasses include phosphosphingolipids, with head groups attached through phosphodiester linkages. 

Phosphosphingolipid Lipid containing a sphingoid base and a phosphorous. 

SM is the major phosphosphingolipid in mammalian tissues and lipoproteins, and has been studied extensively with respect to its role in the formation of sterol-enriched ordered membrane domains and cell signaling (J. Slotte, 2006). Like Cers (and most other complex sphingolipids), SMs typically have high phase-transition temperatures (>37°C), which is a factor in their tendency to associate with rafts. 

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