Phosphorous acid dichloride

With phosphoryl chloride in alkali, imidazole gives the diphosphoryl imidazole (71) while 1-methylimidazole gives an analogous product. Such iV-phosphorylimidazoles play an important role in enzymic transphosphorylation. When two moles of imidazole (or benzimidazole) react with one mole of dialkyl (or diaryl) phosphoric acid chloride, the compounds (72) are formed, and di- and tri-imidazolides of phosphoric acid (e.g. 73) can be obtained similarly from phosphoric acid dichloride or from phosphoryl chloride (Scheme... 

QH CljNOjP]- 0-(2,2,6,6-Tetramethyl-4-piperidinyl-l-oxyl) phosphoric acid dichloride Reaction of EPR/ 300 N 1.57 73Sos2... 

By acylation of amines with active derivatives of a-keto acids pyruvic acid chloride (767), p-nitrophenyl pyruvate 167, 169), carbodimide method 86. 166, 178), mixed anhydrides with phosphorous acid dichloride 436) and by activation with the cyclic esters of oxalic acid with 4,6-diphenyl-thieno-[3,4-d]-[l,3]-dioxolone-dioxide (H. Schmidt and W. Steglich, 346A). 

N,N -Bis( -chloroethyl)phosphoric acid amide dichloride T riethylamine 1,3-Propanolamine... 

N,N-bis-(2phosphoric acid amide dichloride N-(2-ChloroethyI)-N-(3-hydroxypropyl)-amine hydrochloride Triethylamine... 

N,N -Bis(/3phosphoric acid amide dichloride Cyclophosphamide Defosfamide T rofosfamide... 

Labeled phosphoric acid triesters and diamides have been synthesized from phosphoric diimidazolide.tl92],tl93] This method was found to be superior to that involving the dichloridate (phosphoric dichlorides). 

Not only phosphines or phosphites but also phosphoric acid trisdialkyl-amides (40), sulfoxides (41), etc. have been used as electron donors in the preparation of the catalyst. In addition, the catalytic activity of tetra-methylcyclobutadienenickel dichloride and alkylaluminum halides has been studied in detail (42, 43). 

The probable impurities in radioactive phosphorus trichloride are hydrogen chloride and phosphorous acid the trichloride is, therefore, purified by fractional evaporation and fractional condensation in the high-vacuum system. Pure ethylphosphonous dichloride is prepared according to the equation ... 

Phenylhydrazine Hydrochloride Phenylhydrazinium Chloride Phenyl Hydroxide Phenylmethanol Phenylmethyl Alcohol Phenylmethyl Amine Phenylphosphine Dichloride Phenylphosphine Thiodichloride Phenylphosphonothioic Dichloride Phenyl Phosphonous Dichloride Phenylpropylene 1 -Phenyltetradecane 1-Phenylundecane Phosgene Phosphoric Acid Phosphoric Sulfide... 

A solution of 7.5 g (0.1 mol) of 1,3-propanolamine and 20.2 g of triethylamine in 100 cc of absolute dioxane is added dropwise at 25°C to 30°C while stirring well to a solution of 25.9 g (0.1 mol) of N,N-bis-(p-chloroethyl)-phosphoric acid amide dichloride in 100 cc of absolute dioxane. After the reaction is complete, the product is separated from the precipitated triethylamine hydrochloride and the filtrate is concentrated by evaporation in waterjet vacuum at 35°C. The residue is dissolved in a large amount of ether and mixed to saturation with water. The N,N-bis-(p-chloroethyl)-N,O-propylene phosphoric acid diamide crystallizes out of the ethereal solution, after it has stood for some time in a refrigerator, in the form of colorless water-soluble crystals. MP 48°C to 49°C. Yield 65% to 70% of the theoretical. 

Epoxy Adducts. The epoxy resin itself may be reacted with di- or polyfunctional reactants containing more than one epoxy group. The number of potential epoxy adducts is very large. Typical are phosphorous-containing epoxy resins prepared by reaction of diepoxies with acid dichlorides of phosphoric acids. This is accomplished at an acid diepoxy ratio of 1 2 in the presence of FeCl3 catalyst. Adducts may also be prepared by the reaction of chain hydroxyls. 

Various compounds of platinum dichloride with phosphorus trichloride and with phosphorous acid have been prepared.5... 

Numerous phosphoric acid ester amides and thio analogs, (R0)P(Q)(NR2)2 and (RO)2P(Q)(NR9 are also known. Among these, (ArO)P(S)(NH2)2 are cited they can be prepared from the dichloride in liquid ammonia. ... 

This cleavage reaction can be performed with a host of reagents phosphorous pentachloride, benzenesulfonyl chloride, phosphoric acid, thionyl chloride, phosphonitrile dichloride, and dichlorocarbene. All these reactions, nevertheless, use conceptually the very same construction of an ester followed... 

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