Phosphonate ethane

MePO2- or PME2- (Table XIX), but the open closed equilibrium lies very much on the side of the chelated form of the complex (87% for the Ca2+ complex - compare 15% for [Ca(atp)]2 and just 7% for [Ca(amp)] (695)). The availability of stability constants both for methylphosphonate and for benzimidazole (a purine model) complexes means that the chelate effect for complexes of (1H-benzimidazol-2-yl-methyl)phosphonate can be discussed without the usual complications, such as the differences between ethane-1,2-diamine and two ammonia or two methylamine ligands and disparities between units (704). 

King, W. R., Francis, M. D., Michael, W. R. Effect of disodium-ethane-1 -hydroxy-1,1-di-phosphonate on bone formation. Clin. Orthop. 78, 251 (1971)... 

Phosphonate Diethyl 1-Fluoro-ethane ElOa. 482 (H > F) Phosphoryl Fluoridate Diisopropyl ElOa, 50 (Toxicity)... 

Phosphonate Diethyl 2-Chloro-2,2-difluoro-1 -hydroxy-1 -methyl-ethane ElOb. 681 [F2CIO-CO-R + H-PO(RO)2]... 

Phosphonate Dipropvl 1-Fluoro-1,2,2-trichloro-ethane ElOb, 678 (CI2C = CFC1 + H-POX,) E10b2. 153 (Educt)... 

Phosphonate Dibutyl l-Hydroxy-2,2,2-trifluoro-ethane ElOb, 682 [F3C-CH(OH)-OR + (RO)2P-OH]... 

Phosphonate Bis-[trimethylsilyl] Difluoro-2-(nonafluoro-butyl-oxy)-ethane ElOb, 675 (P - POX2)... 

Phosphonate Diethyl 2-Chloro-l-cyclohcxyl-2.2-difluoro-l -hydroxy-ethane ElOb,. 681 [C1F,C — CO — R +... 

Phosphonate Diethyl l-(Diphenyl-methyUtmino)-2,2,2-trifluoro-ethane- E10b,. 675 [Cl - PO(OR)2]... 

Phosphonic Acid l-Amtno-2-hydroxy-ethan- E2Ie, 5725 [Nitron + R-CHO/... 

SYNS DEQUEST 2010 DEQUEST 2015 DEQUEST ZOlO EHDP ETHANE-l-HYDROXY-Ll-DIPHO-SPHONATE 1,1,1-ETHANETRIOLDIPHOSPHONATE ETIDRONIC ACID FERROFOS 510 HEDP 1-HYDROX -l,l-DIPHOSPHONOETHANE HYDROXY-ETHANEDIPHOSPHONIC ACID 1-HYDROXY-ETHANEDIPHOSPHONIC ACID OXYETHYL-IDENEDIPHOSPHONIC ACID PHOSPHONIC ACID, 1-HYDROX -l,l-ETHANEDIYL ESTER PHOSPHONIC ACID, (l-HYDROXYETHYLIDENE)BIS- lOOOSL TURPINAL SL... 

Phosphine Chalcogenides as Ligands. - The complexation of lanthanide and actinide ions by phosphine oxide ligands remains an active area, and a theoretical assessment of the coordination of phosphine oxides (and phosphate esters) by trivalent lanthanide ions has appeared." Trivalent lanthanide complexes of the functionalised enol phosphine oxide (265), (and a related phosphonate), have been describedComplexes of thorium(iv) with bis(di-phenylphosphino) ethane dioxide and bis(diphenylphosphinoyl)amide have also been characterised." Calixarene systems which bear phosphine oxide... 

Additional support for a free radical mechanism of the copper catalyzed reaction of red phosphorus with CH3CI or benzyl chloride comes from the isolation of methane, ethane, ethylene and propene in the CH3Cl-reaction and of trans stilbene and toluene in the PhCH2Cl-reaction, in addition to phosphonous dichlorides, RPCI2 (R = CH3, CgHjCHj ) 51) ... 

Nakano, M., Okamoto, Y., and Sakurai, H., Preparation of dialkyl 2-cyano-2-(trimethylsilyl)ethane-phosphonates. Synthesis, 915, 1982. 

The synthesis of polyphosphines containing combinations of primary, secondary, and tertiary phosphorus atoms by the base-catalysed addition of P—H across the carbon-carbon double bond of vinyl phosphonates, followed by reduetion with lithium aluminium hydride, has again been described. The preparation of I,2-bis(phosphino)ethane from the bis-phosphonate (17) by reduction with lithium aluminium hydride has been reported in detail. ... 

Independent of these workers, Lorenz et al. (1955) found that 0,0-dimethyl-(l-hydroxy-2,2,2-trichloro)ethane phosphonate (trichlorfon, 68), to be discussed later, on interaction with alkali loses one mole of hydrogen chloride, and that subsequent rearrangement also yields product 67 (dichlorvos, DDVP). 

Diethylenelriaminepenta(methylenephosphonic)acid. Diethylenetriamine, pentamethylenepentaphosphonic Diethylerietriaminepenta(methylenephosphoriic) acid EINECS 239-931-4 Phosphonic acid, (((phosphono-methyl)imino)bis(2,1-ethanediylnitrilobis-(methylene)))tetrakis- (((Phosphonomethyl)imino)bis-(ethane-2,1-diylnitrilobis(methylene)))tetrakisphosphonic acid. 

In the only reported examples (107) of the Michaelis-Arbuzov reaction with optically active halides (2-halooctane and 1-halophenyl-ethane), results were inconclusive. The halides underwent extensive racemization in preference to furnishing the expected phosphonate. The stereochemical nature of the attack by phosphite on alkyl halides could perhaps be clarified by the use of optically active primary deutero-halides (RC DHX), wherein steric hindrance is at a minimum, and one could more easily obtain phosphonate products. No experiments of this type have been reported. 

The addition of a nitroalkane to an alkenylphosphonic diester is exemplified by the interaction of nitromethane with diethyl ethenylphosphonate in the presence of NaOEt, when the product is diethyl (3-nitropropyl)phosphonate and by a similar addition to 1,1-bis(diethoxyphosphinoyl)ethane . In the initial stages of a synthesis of (4,5,6-trihydroxy-3-oxohexyl)phosphonic acid, the nitro sugar 76 was made to add to dibenzyl ethenylphosphonate, but the resultant (3-nitropropyl)phosphonic dibenzyl ester 77 was then used without isolation. ... 

In the presence of piperidine in benzene, benzaldehyde reacts with diethyl (nitromethyl)-phosphonate to afford at 67% yield of diethyl (2-hydroxy-l-nitro-2-phenylethyl)phos-phonate, presumably as a mixture of diastereoisomers. However, a similar reaction with 4-nitrobenzaldehyde leads to phosphorus-carbon bond cleavage and the formation of 1-nitro-2-(4-nitrophenyl)ethane. The converse procedure, i.e. a reaction which involves a nitroalkane and an (oxoalkyl)phosphonic diester, is also subject to certain restrictions. The base-catalysed nucleophilic additions of nitromethane to dialkyl acetylphosphonates (Scheme 7 R = Me) to give dialkyl [(1-hydroxy-l-nitromethyl)alkyl]phosphonates have... 

The photochemical cleavage of the phosphorus-carbon bond in many benzylic phosphonic acids occurs through intramolecular electron transfer and gives monomeric metaphosphate together with substituted toluenes and, in many cases, 1,2-diarylethanes. The ultraviolet irradiation of (4-nitrobenzyl)phosphonic acid dianion in solution in aqueous ethanol yields l,2-bis(4-nitrophenyl)ethane, 4-nitrotoluene, H3PO4 and monoethyl phosphate (Scheme Irradiation of the same acid in the presence of dbu (other tertiary... 

Hydration in the presence of mercury(II) sulphate yields an (oxoalkyl) compound (equation The treatment of the phosphonic ester 364 (R = Et, Z= P03Et2) with a thiolate leads, via diethyl ethynylphosphonate, to the ethenylphosphonic diester 365 with the concomitant formation of thiophosphate ester in this particular case, the product 365 as initially formed, is of Z geometry, but isomerizes when distilled . In other cases of the reactions with thiols, for instance with 364 (R = Et, Z = Cl), the direct replacement of Z is accompanied by overall displacement plus addition at each carbon to give products of types 366 (as a mixture of E and Z stereoisomers) and 367. The same substrate 364 (R = Et, Z = Cl) with the monosodium salt of ethane-1,2-diol represents an alternative route (substitution followed by addition) to 361, but with more basic nucleophiles such as Bu O, and even MeO , cleavage of the phosphorus-carbon bond occurs, although the extent of this decreases, and the extent of addition (with EtO and PhO ) increases, when R = Me is replaced by R = Et. The additions of arylsulphenyl chlorides to 364 (R = Et, Z = Me) occur stereoselectively to give only the E products . 

The reactions of dimethyl methylphosphonate and the corresponding carbanion in the gas phase have been investigated. The carbanion displays a similar range of reactions to those encountered in solution, including olefmation with carbonyl compounds. The effect on olefin stereochemistry of a variety of conditions in reactions of a-phosphono lactones (e.g. 129) with ethanal and propanal has been studied and the results applied in syntheses of integerrinecic acid and senecic acid lactones. Yet further minor modifications of the conditions for phosphonate-olefination reactions, involving the use of lithium hydroxide as the base, have been reported. ... 

Fig. 4 Frequency of detection for selected pesticides (red bars) and their transformation products (blue bars) from 86 municipal wells sampled in Iowa during 2001 [48]. ESA -ethane sulfonic acid OXA - oxanUic acid AMPA - aminomethyl phosphonic acid...

CAS 3794-83-0 EINECS/ELINCS 223-267-7 Synonyms Ethane-1-hydroxy-1,1-diphosphonic acid, tetrasodium salt (1-Flydroxyethylidene) bisphosphonic acid, tetrasodium salt (1-Fly-droxyethylidene) diphosphonic acid, tetrasodium salt 1-Flydroxyeth-ylidene-1,1 -diphosphonic acid, tetrasodium salt NaiFIEDP Phosphonic acid, (1-hydroxyethylidene) bis-, tetrasodium salt Tetrasodium 1-hydroxyethane-1,1 -diphosphonate Tetrasodium (1 -hydroxyethylidene) bisphosphonate Tetrasodium 1 -hydroxyethylidene-1,1 -diphosphonate Classification Diphosphonic acid deriv. 

Ethane-1 -hydroxy-1 -1 di phosphonic acid disodium salt. See. Disodium etidronate Ethane-1 -hydroxy-1,1 -diphosphonic acid, tetrasodium salt. See Tetrasodium etidronate Ethane, 1,1 -[methylenebis (oxy)] bis-. See Diethoxymethane... 

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