Phospholipidosis drug-induced

LuIIman H, LuIImann-Rauch R, Wassermann O, et al. Drug induced phospholipidosis. CRC Critical Rev Toxicol 1975 4 185-218. 

Studies have been performed to elucidate the molecular basis of drug-induced phospholipidosis. It has been found that, in the case of drugs of the chlorphenter-... 

Nonoyama T, Fakuda R. Drug-induced phospholipidosis - Pathological aspects and prediction. /. Toxicol. Pathol. 2008 21 9-24. 

Reasor MJ, Kacew S. Drug-induced phospholipidosis Are there functional consequences Exp Biol Med (Maywood). 2001 226(9) 825-830. 

Nioi P, Perry BK, Wang EJ, et al. In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 99(1) 162-173. 

Halliwell WH (1997) Cationic amphiphilic drug-induced phospholipidosis. Toxicol Pathol 25(l) 53-60... 

Phospholipidosis Phospholipidosis is a lipid storage disorder which is characterized by lamellar body formation and excess phospholipid accumulation within cells. Drug-induced phospholipidosis is an adverse drug reaction that occurs with many cationic amphiphilic drugs. 

Anderson N, Borlak J (2006) Drug-induced phospholipidosis. FEBS Lett 580 5533-5540... 

Nonoyama, T., and R. Fukuda. 2008. Drug-induced phospholipidosis—Pathological aspects and its prediction. Journal of Toxicology and Pathology 21 9-24. 

Tengstrand Baronas, E., J-W. Lee, C. Alden, and E. Y. Hsieh. 2006. Biomarkers to monitor drug-induced phospholipidosis. Toxicology and Applied Pharmacology 216 72-76. 

DRUG-INDUCED GENE EXPRESSION AND PHOSPHOLIPIDOSIS IN HUMAN HEPATOMA HEPG2 CELLS... 

FIGURE 3.4 The process used in this work to identify gene expression levels associated with drug-induced phospholipidosis in HepG2 cells. 

TABLE 3.10 Eleven Top Rules Describing the Relationship of Gene-Expression Levels to Drug-Induced Phospholipidosis in Hepatoma HepG2 Cells ... 

Reasor MJ, Hastings KL, Ulrich RG. Drug-induced phospholipidosis issues and future directions. Expert Opin Drug Safety 2006 5 567-583. 

Nonoyama T, Fukuda R. Drug induced phospholipidosis pathological aspects and its prediction. J Toxicol Pathol 2008 21 9-24. 

H. Sawada, K. Takami and S. Asahi, A toxigenomic approach to drug-induced phospholipidosis Analysis of its induction mechanism and establishment of a novel in vitro screening system, Toxicol. Sci., 2005, 83, 282-292. 

There are specific fiuorescent dyes for specific pathologies created by specific drug classes, such as phospholipidosis from cationic amphiphilic drugs [18, 19], mitochondrial DNA depletion by nucleoside reverse transcriptase inhibitors that also inhibit mitochondrial DNA polymerase gamma and redox cyclers that produce reactive oxygen species. The complex mechanism of statin-induced toxicity is demonstrated vith early sublethal effects on apoptosis, mitochondrial function and calcium homeostasis [20]. 

Aleo MD, Navetta KA, Emeigh Hart SG et al. (2002) Mechanism-based urinary biomarkers of aminoglycoside-induced phospholipidosis. Comp Clin Pathol 11 193-194 Aleo MD, Navetta KA, Emeigh Hart SG et al. (2003) Mechanism-based urinary biomarkers of renal phospholipidosis and injury. Toxicol Sci 72 (Suppl) 243 Bandara LR, Kennedy S (2002) Toxicoproteomics - a new pre-clinical tool. Drug Disc Today 7 411—418 Chapman K (2002) The ProteinChip biomarker system from Ci-phergen Biosystems a novel proteomics platform for rapid biomarker discovery and validation. Biochem Soci Trans 30 82-87... 

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