Cyclic Phosphonates and Caged Bicyclic Phosphates

According to our study on the alkylphosphonates lA-IK series, in the structure lo, both R and R groups in the structural unit of phosphoras-containing played a very important role in both herbicidal activity and inhibition against plant PDHc El. We noticed that a variety of studies had demonstrated that bioactivity and stability of phosphonates or phosphates could be increased by introducing a phosphorus-containing heterocyclic moiety to their parent structure [22, 23]. 

In this chapter, we focus on the synthesis, herbicidal activity, and stmcture-activity relationship of cyclic phosphonates IVA-IVF, and caged bicyclic phosphates IVG-IVH. Indeed, the bioassay results showed that several cyclic phosphonates exhibited promising herbicidal activity and potential utility as herbicides. 

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Chapters 2-5 focus on the synthesis, spectroscopic analysis, and herbicidal activity of 30 series phosphorus-containing compounds including alkylphosphonates, monosalts of alkylphosphonic acids, alkylphosphinates, monosalts of alkylphosphinic acids, cyclic phosphonates, and caged bicyclic phosphates (Scheme 1.20). Their stmcture-activity relationships are discussed in detail in each chapter. 

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