Phorbol ester-induced activation

Kundu JK, Surh YJ. 2007. Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin Role of p38 MAP K. Ann N Y Acad Sci 1095 504-512. 

NAKA M, NISHKAWA M, ADELSTEIN RS, HDAKA H. Phorbol ester-induced activation of human platelets is associated with protein kinase C pho horylation of myosin light chains. Nature306 490-492,1983. 

Han, S.S. et al.. Capsaicin suppresses phorbol ester-induced activation ofNF-kB/Rel and AP-1 transcription factors in mouse epidermis. Cancer Lett., 164, 119, 2001. 

Bamberger AM, Bamberger CM, Wald M, Kratzmeier M, Schulte HM (1996) Protein kinase C (PKC) isoenzyme expression pattern as an indicator of proliferative activity in uterine tumor cells. Mol Cell Endocrinol 123 81-88 Basu A, Teicher BA, Lazo JS (1990) Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to ds-diamminedichloroplatinum(II) J Biol Chem 265 8451-8457... 

Gravitt KR, Ward NE, Fan D, Skibber JM, Levin B, O Brian CA (1994) Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells. Biochem Pharmacol 48 375-381... 

MacFarlane DE, Manzel L (1994) Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and suifident for phorbol ester-induced differentiation of HL-60 promyelocytes. Studies with PKC beta-defective PET mutant. J Biol Chem 269 4327-4331... 

Ward NE, O Brian CA (1991) Distinct patterns of phorbol ester-induced downr -lation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells. Cancer Lett 58 189-193 Warenius HM, Seabra LA, Maw P (1996) Sensitivity to cis-diamminedichloro-platinum in human cancer cells is related to ejq>ression of cyclin D1 but not c-raf-1 protein. Int J Cancer 67 224-231... 

ZO024 Park, K. K., K. S. Chum, ]. M. Lee, S. S. Lee, and Y. ]. Surh. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett 1998 129(2) 139-144. 

Luyengi, L. et al., Rotenoids and chalcones from Mundulea sericea that inhibit phorbol ester-induced ornithine decarboxylase activity. Phytochemistry, 36, 1523, 1994. 

Xu, . X., Jin, H, Chung, Y. S., Shin, J. Y., Lee, . H., Beck, G. R., Palmos, G. N., Choi, B. D., and Cho, M. H. (2008a). Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of inflammatory factors VCAM-1 and COX-2 by blocking NF- activation in mouse skin. J. Agric. Food Chem. 56, 9667-9675. 

Kundu JK, Shin YK, Kim SH, Surh Y-J. 2006a. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kB in mouse skin by blocking I B kinase activity. Carcinogenesis 27 1465-1474... 

Gupta, A.K., Fisher, G.J., Elder, J.T., Nickoloff, B.J., and Voorhees, J.J., Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin, J. Invest. Dermatol., 91, 486-491, 1988. 

Hunzicker-Dunn et al. [73] and Ezra and Salomon [74] suggested that the desensitization of the ovarian adenylate cyclase system by LH involves a phosphorylation reaction. The latter may alter the conformation of the receptor and/or Gs. If phosphorylation is the mechanism it may well be mediated by protein kinase C because phorbol esters, which are presumed to activate this enzyme, mimic LH induced desensitization in Leydig tumour cells [75,76]. There are, however, differences between LH- and phorbol ester induced desensitization [76], Cyclic AMP-dependent protein kinase is probably not involved because dibutyryl cyclic AMP does not mimic LH induced desensitization in Leydig cells [70]. 

Cytotoxicity (MCF-7 and Hepa lclc7 cells) of the stilbenes in cube resin from Lonchocarpus utilus and L. urucu roots paralleled their inhibition of NADHmbiquinone oxidoreductase activity and phorbol ester-induced ornithine decarboxylase activity [50,467]. 

Phosphorylation of LC20 in permeabilized gizzard smooth muscle by direct addition of PKC (Sutton and Haeberle, 1990) or its constitutively active proteolytic fragment, PKM (Parente et al., 1992), results in phosphorylation of LC20 mainly on Seri 2 with a small amount on Thr. The only mechanical response observed in those studies in response to direct addition of PKC or PKM was an attenuation of Ca +-induced contraction in permeabilized gizzard smooth muscle fibers (Parente et al., 1992). Phorbol ester-induced attenuation of contractile responses has been observed in ileal and uterine smooth muscle (Baraban et al.,... 

Viaje, A., T.J. Siege, M. Wigler, and LB. Weinstein Effects of anti-inflammatory agents in mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator Cancer Res. 37 (1977) 1530-1536. Viart, P. Aromatization of tobacco. Determination of coumarin, dihydrocoumarin, ethylvanUhn and vanillin in tobacco and its smoke Aim. Dir. Emdes Equipement, SETTA 8(Sect. 1) (1970) 151-152. 

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