Phenoxy ethanol-benzene

Numerous different mechanistic approaches have been applied for this combination. First, cyclization of phenoxy-ethanols 203, in the presence of (diacetoxyiodo)benzene and iodine, gave a mixture of 1,4-benzodioxane 13 and 6-iodo-l,4-benzodioxane 204 via alkoxy radicals (Equation 36) <1997J(P 1)787, 1996TL2441>. 

To a solution of 1 gramm equivalent (g-eq.) of l-bromo-3-[2-(tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1 g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the ethanol is distilled off. The residue is dissolved in benzene and the solution is extracted twice with 5% oxalic acid. The aqueous extract is made alkaline with potassium hydroxide and the isolated oil is extracted with benzene. The benzene extract is dried over potassium carbonate and the benzene is distilled off to give of oily l-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2-propanol. The corresponding acid fumarate melts at 128°-132°C. 

Quantum yields of phototransformations of phenoxy-substituted naphthacene-quinones depended on the nature of the solvent.59 One can see from Table 7.7 that the replacement of benzene by ethanol led to a decrease in the quantum yield of the ana form. At the same time, the quantum yield of the photodegradation of the ana form increased. 

In an in vitro percutaneous study performed on rodent and pig skin with DEBT (diethyl-m-toluamide CAS no. 134-62-3), permethrin and carbaryl results were that no permethrin was absorbed. It was believed by the authors that DEBT inhibited the absorption of permethrin (Baynes et al. 1997). Bast et al. (1997) studied the percutaneous absorption of permethrin through the isolated perfused rabbit ear. Permethrin was applied in isopropyl myristate (reference ointment) or in ethanol. The ethanol was evaporated off skin, and the skin was covered with 1.5 (w/w) methyl cellulose in water. The authors measured the appearance rates (pmol min cm ) of 3-phenoxy benzene methanol (CAS no. 13826-35-2) and 3-phenoxybenzoic acid (CAS no. 3739-38-6) in the effusate after dermal application (3.61 pmol cm of skin). No permethrin per se was found in the effusate. The metabolites were believed to be from impurities in the permethrin. From the concentration that permethrin constitutes in a pharmaceutical brand (Ambush ) and from detection limits. Bast et al. (1997) calculated a Kp of 2.63 x 10 cm h . ... 

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