Phenothiazine Promethazine hydrochloride

Brompheniramine maleate Chlorpheniramine maleate Dexchlorpheniramine maleate Ethanolamine class, nonselective Carbinoxamine maleate Clemastine fumarate Diphenhydramine hydrochloride Ethylenediamine class, nonselective Pyrilamine maleate Tripelennamine hydrochloride Phenothiazine class, nonselective Promethazine hydrochloride Piperidine class, nonselective Cyproheptadine hydrochloride Phenindamine tartrate... 

Phenothiazine derivatives promethazine hydrochloride trimeprazine tartrate... 

Phenothiazine class, nonselective Promethazine hydrochloride Piperidine class, nonselective High High... 

Promethazine hydrochloride, a phenothiazine derivative, is designated chemically as 10 H-phenothiazine-10-ethanamine,N,N,(alpha)-trimethyl-,monohydrochloride, ( )-. 

In the guinea-pig, promethazine hydrochloride in an oral dose of200 mg/kg prevents ultra-violet erythema, although three other non-phenothiazine... 

It is interesting to observe that in the promethazine hydrochloride moleeule the two carbon chain is linked with an iso-propyl moiety, but the presence of the phenothiazine group might exert better therapeutic effect on the molecules as such. 

Propiomazine hydrochloride is designated by the following chemical names ll0-(2-dimethylaminopropyl)-2-propionylphenothiazine hydrochloride, and propionyl-promethazine hydrochloride , In the subject indices of Chemical Abstracts, the compound is listed under the heading l-[10-l2-(dimethylamino) propyl] phenothiazin-... 

A study in healthy subjects found that intramuscular promethazine hydrochloride 25 mg, given with intramuscular chloroquine phosphate 200 mg increased the AUC of chloroquine and its metabolites by 85%. This may be due to promethazine enhancing the absorption of chloroquine from the injection site or displacing it and its metabolites from binding sites in the blood. The initial rate of excretion of chloroquine and the total drug excreted within 3 hours was unaffected by promethazine. The increased bioavailability of chloroquine may improve its therapeutic effects but could also increase toxicity. In vitro and animal studies suggest the combination may be effective in the treatment of uncomplicated chloroquine-resistant malaria. More study is needed. For mention that chloroquine may increase chlorpromazine levels, see Phenothiazines + Antimalarials , p.759. 

Although topical phenothiazine antihistamine preparations such as promethazine hydrochloride (Phenergan) cream are no longer used in the United States, such topical antihistamine preparations are still widely used in Europe. Individuals who have become sensitized by such topical phenothiazine antihistamines often suffer a flare of the dermatitis when a phenothiazine antihistamine is taken, i.e., a systemic eczematous contact dermatitis. In addition, many individuals acquire allergic sensitization to various phenothiazine drugs which show cross-reactions with the phenothiazine antihistamines. Table 6 lists the phenothiazine antihistamine compounds. 

Alam, Md. S. Mandal, A. Mandal, A. B. Effect of KCl on the Micellization and Clouding Phenomenon of Amphiphilic Phenothiazine Drug Promethazine Hydrochloride Some Thermodynamic Properties. /. Chem. Eng. Data 2011, 56,1540-1546. 

Kabir-ud-Din Rub, M. A. Alam, Md. S. Micellization and Clouding Phenomenon of Phenothiazine Drug Promethazine Hydrochloride Effect of NaCl and Urea Addition. /, Dispersion Sci. Technol, 2010, 31,1182-1187. 

An aqueous solution of the antihistamine, promethazine (361) hydrochloride, was photolysed to promethazine sulphoxide, phenothiazine, phenothiazine sulphoxide and 3//-phenothiazin-3-one (362) [206]. 

Interestingly, penicillamine—a degradation product of penicillin and phenothiazines—the histamine H,—receptor antagonists, such as promethazine teoclate, methadilazine hydrochloride, trimeprazine tartrate are found to increase the cholesterol levels. 

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