Phenolic disinfectants

Flood with a phenolic disinfectant any biologically contaminated area for 30 to 60 min and then clean up with water and allow to dry. After cleaning up wash hands with a suitable skin disinfectant (such as 0.5% Chlorhexidine in 70% methylated spirit)... 

Fig. 10.7 Structural formulae of phenolic disinfectants A, clear soluble fluids B, black and white fluids C, chlorinated phenols D, bisphenols.

The phenols from the higher boiling point fractions have greater antimicrobial activity but must be formulated so as to overcome their poor solubility. A range of solubilized and emulsified phenolic disinfectants are available including the clear soluble fluids,... 

Cleaning/Disinfecting Equipment Terminal cleaning required with phenolic, disinfect surfaces with 1 9 bleach/water solution (10 percent), linen double bagged, disinfect equipment before taking it from room, change air filter before room terminally cleaned. 

A second series of reports in the literature purport to discuss the toxicity of phenol to newborns. These, however, deal with an excessive level of hyperbilirubinemia, or jaundice, in newborns in hospital nurseries where a phenolic disinfectant detergent was used to clean the nursery and its equipment (bassinets and mattresses) (Doan et al. 1979, Wysowski et al. 1978). Review of these reports indicated that the detergent did not contain phenol per se. rather it contained more complex phenolics such as o-benzyl-p-chlorophenol and p-tertiary amylphenol. 

Spiller HA, Quandrani-Kushner DA, Cleveland P. 1993. A five year evaluation of acute exposures to phenol disinfectant (26%). J Toxicol Clin Toxicol 31 307-313. 

Starr JE, Judis J. 1968. Mechanism of action of phenolic disinfectants 8. Association of phenolic disinfectants with proteins. J Pharm Sci 57 768-773. 

Wysowski DK, Flynt JW, Goldfield M, et al. 1978. Epidemic neonatal hyperbilirubinemia and use of a phenolic disinfectant detergent. Pediatrics 61 165-170. 

Luessem H. 1975. Effect of phenolic disinfectants on waste water treatment. Vom Wasser 45 327-334. 

Phenolic disinfectants are used for hard surface decontamination in hospitals and laboratories, eg, floors, beds, and counter or bench tops. They are not recommended for use in nurseries and especially in bassinets, where their use has been associated with hyperbilirubinemia. Use of hexachlorophene as a skin disinfectant has caused cerebral edema and convulsions in premature infants and occasionally in adults. 

Propofol has a remarkably simple structure resembling that of phenol disinfectants. Because the substance is water-insoluble, an injectable emulsion is prepared by means of soy oil, phosphatide, and glycerol. The effect has a rapid onset and decays quickly, being experienced by the patient as fairly pleasant. The intensity of the effect can be well controlled during prolonged administration. Possible adverse reactions include hypotension and respiratory depression, and a potentially fatal syndrome of bronchospasm, hypotension, and erythema. 

Neonatal jaundice has been associated with the use of phenolic disinfectants in nurseries, not only when used in excessive concentrations, but also when applied in the recommended dilution (SEDA-5, 258) (SEDA-8, 246) (SEDA-11, 484). 

Judis J. Studies on the mechanism of action of phenolic disinfectants I. / Pharm Sci 1962 51 261-265. 

Phenol coefficient tests were developed in the early 20th century when typhoid fever was a significant public health problem and phenolics were used to disinfect contaminated utensils and other inanimate objects. Details of such tests can be found in earlier editions of this book. However, as non-phenolic disinfectants became more widely available, tests that more closely paralleled the conditions under which disinfectants were being used (e.g. blood spills) and which included a more diverse range of microbial types (e.g. viruses, bacteria, fungi, protozoa) were developed. Evaluation of a disinfectant s efficacy was based on its ability to kill microbes, i.e. its cidal activity, under environmental conditions mimicking as closely as possible real life situations. As an essential component of each test was a final viability assay, removal or neutralization of any residual disinfectant became a significant consideration. 

It has a semi-sweet, tarry-medicinal odor, tar-like, smokey (Arctander, 1967) burnt, guaiacol-like (from Kim Ha and Lindsay, 1991). The flavor is chemical, phenolic, disinfectant (Chemisis, 1963). 

NipaddeC>FTAP. [N Labs] p-t-Amyl phenol disinfectant for indns use. 

Biological waste can also be disinfected with chemical agents such as bleach or phenolic disinfecting agents. The most common agent is bleach since it is inexpensive and will likely result in a product that can be disposed of down the sanitary sewer. Other chemical disinfection may result in chemical waste that needs further handing by chemical waste management. 

A variety of industries produce phenolic or similar aromatic waste streams, mainly as by-products of specific chemical manufacture, but also associated with coking, refinery, tar distillery and foundry operations. Use of phenolic disinfectants ultimately leads to these compounds appearing in effluents. 

Chlorinated phenol - 254 Chlorinated phenol disinfectant -187 Chlorinated pulp stock -187 Chlorinated rubber polymer -187 Chlorinated solvent - 32, 36, 46, 156, 297, 357, 639,825,860 Chlorinated TSP - 840 Chlorinated washer hoods -187 Chlorinated water (see also Chlorine water) - 33, 34, 35, 37, 74, 221, 645, 676, 677, 735, 774, 780... 

Pentachloro phenol 9 Confusion, lethargy, tachycardia, hypolfflision, metabolic acidosis, hepatic and renal injury, swelling and hypalgesia of the skin Manufacture of phenolic resins, plastics, explosives, fertilizers, paints, pharmaceuticals, paper, phenolic disinfectants 0.005-0.01 pg/1 by GC with ECD... 

Uses Coupling agent for built detergents, phenolic disinfectants, and liq. cleaners Features Low vise. 

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