Phencyclidine drug administration

Woolverton, W.L. Martin, B.R. and Balster, R.L. Modification of the behavioral effects of phencyclidine by repeated drug administration and body weight changes. Pharmacol Bi ochem Behav 12 761-766, 1980. 

Abuse of phencyclidine hydrochloride (PCP) is a national problem that has reached epidemic proportions in urban areas of the United States. The drug is inexpensive, readily obtainable, and is usually used in combination with other drugs such as marijuana, heroin, cocaine, and alcohol (Golden et al. 1982). The routes of PCP use include inhalation, ingestion and parenteral administration. 

Slifer, B.L., Woolverton, W.L., and Balster, R.L. Behavioral dependence in Rhesus monkeys with chronic phencyclidine administration. In Harris, L.S., editor. Problems of Drug Dependence, 1981. National Institute on Drug Abuse, Rockville, Md. NIDA Research Monograph 41, 1982. p. 184-189. 

Phencyclidine, commonly known as PCP, is a difficult drug to categorize. The United States Drug Enforcement Administration (DEA) categorizes it as a hallucinogen, like LSD, because it can make people see, hear,... 

U.S. Department of Justice Drag Enforcement Administration. Phencyclidine (PCP). Drugs of Concern [Cited March 26, 2002]. . 

The National Household Survey on Drug Abuse (NHSDA), which is conducted by the Substance Abuse and Mental Health Services Administration (SAMH-SA), provides statistical data on illegal drug use in the United States. For the purpose of the survey, hallucinogenic drugs were defined to include lysergic acid diethylamide (LSD), phencyclidine (PCP), psilocybin, peyote, and ecstasy. 

Psilocybin, mescaline, and LSD have similar central (via serotonergic systems) and peripheral (sympathomimetic) effects. None of these hallucinogenic drugs have been shown to have teratogenic potential. Contrast this with the established potential for teratogenicity or other fetal toxicity with abuse of ethanol, amphetamines, and cocaine. Unlike most hallucinogens, phencyclidine acts as a positive reinforcer of self-administration in animals. Scopolamine is not a positive reinforcer but does exert atropine-like effects. The answer is (D). 

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